Cell atlas - PNMT - The Human Protein Atlas

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PNMT

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	PNMT
Gene description	Phenylethanolamine N-methyltransferase
Protein class	Cancer-related genes Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to vesicles.
RNA cell category	Cell line enhanced (NB-4, K-562, SCLC-21H, SH-SY5Y)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA051005
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (NB-4, K-562, SCLC-21H, SH-SY5Y) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to vesicles.

Main location

Vesicles (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA051005	HEK 293	Vesicles
	HPA051005	HEK 293	Cell Junctions
	HPA051005	SiHa	Vesicles
	HPA051005	U-2 OS	Nucleoli
			Vesicles
			Intermediate filaments

GENE INFORMATION
Gene name	PNMT (HGNC Symbol)
Synonyms	PENT
Description	Phenylethanolamine N-methyltransferase (HGNC Symbol)
Entrez gene summary	The product of this gene catalyzes the last step of the catecholamine biosynthesis pathway, which methylates norepinephrine to form epinephrine (adrenaline). The enzyme also has beta-carboline 2N-methyltransferase activity. This gene is thought to play a key step in regulating epinephrine production. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]
Chromosome	17
Cytoband	q12
Chromosome location (bp)	39667981 - 39670475
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000141744 (version 83.38)
Entrez gene	5409
UniProt	P11086 (UniProt - Evidence at protein level)
neXtProt	NX_P11086
Antibodypedia	PNMT antibodies

PROTEIN BROWSER

PNMT-001	PNMT-002	PNMT-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PNMT-001 ENSP00000269582 ENST00000269582	P11086 [Direct mapping] Phenylethanolamine N-methyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004603 [phenylethanolamine N-methyltransferase activity] GO:0005829 [cytosol] GO:0008168 [methyltransferase activity] GO:0032259 [methylation] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042418 [epinephrine biosynthetic process] GO:0042423 [catecholamine biosynthetic process] GO:0044281 [small molecule metabolic process] Show all	282 aa 30.9 kDa	No	0
PNMT-002 ENSP00000377791 ENST00000394246	A8MT87 [Direct mapping] Phenylethanolamine N-methyltransferase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008168 [methyltransferase activity] GO:0032259 [methylation] Show all	184 aa 20.6 kDa	No	0
PNMT-003 ENSP00000464234 ENST00000581428	J3QRI3 [Direct mapping] Phenylethanolamine N-methyltransferase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008168 [methyltransferase activity] GO:0032259 [methylation] Show all	137 aa 14.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.