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PNMT

GENERAL INFORMATION

Gene name

 PNMT

Gene description

 Phenylethanolamine N-methyltransferase

Protein class

 Cancer-related genes
Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (adrenal gland)
GTEx:Tissue enhanced (adrenal gland)
FANTOM5:Group enriched (seminal vesicle, caudate, pituitary gland)

Protein evidence

 Evidence at protein level

Protein expression

 Selective cytoplasmic expression in adrenal medulla.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA043412 , HPA051005 , CAB017029
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Adrenal gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (adrenal gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (adrenal gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (seminal vesicle, caudate, pituitary gland)

GENE INFORMATION

Gene name

 PNMT (HGNC Symbol)

Synonyms

 PENT

Description

 Phenylethanolamine N-methyltransferase (HGNC Symbol)

Entrez gene summary

 The product of this gene catalyzes the last step of the catecholamine biosynthesis pathway, which methylates norepinephrine to form epinephrine (adrenaline). The enzyme also has beta-carboline 2N-methyltransferase activity. This gene is thought to play a key step in regulating epinephrine production. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]

Chromosome

 17

Cytoband

 q12

Chromosome location (bp)

 39667981 - 39670475

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000141744 (version 83.38)

Entrez gene

 5409

UniProt

 P11086 (UniProt - Evidence at protein level)

neXtProt

 NX_P11086

Antibodypedia

 PNMT antibodies

PROTEIN BROWSER
PNMT-001
PNMT-002
PNMT-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PNMT-001
ENSP00000269582
ENST00000269582
P11086 [Direct mapping]
Phenylethanolamine N-methyltransferase
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004603 [phenylethanolamine N-methyltransferase activity]
GO:0005829 [cytosol]
GO:0008168 [methyltransferase activity]
GO:0032259 [methylation]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042418 [epinephrine biosynthetic process]
GO:0042423 [catecholamine biosynthetic process]
GO:0044281 [small molecule metabolic process]
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 282 aa
30.9 kDa 		No 0
PNMT-002
ENSP00000377791
ENST00000394246
A8MT87 [Direct mapping]
Phenylethanolamine N-methyltransferase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0008168 [methyltransferase activity]
GO:0032259 [methylation]
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 184 aa
20.6 kDa 		No 0
PNMT-003
ENSP00000464234
ENST00000581428
J3QRI3 [Direct mapping]
Phenylethanolamine N-methyltransferase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008168 [methyltransferase activity]
GO:0032259 [methylation]
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 137 aa
14.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.