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PFKL

GENERAL INFORMATION

Gene name

 PFKL

Gene description

 Phosphofructokinase, liver

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA030047
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PFKL

Synonyms

Description

 Phosphofructokinase, liver (HGNC Symbol)

Entrez gene summary

 This gene encodes the liver (L) subunit of an enzyme that catalyzes the conversion of D-fructose 6-phosphate to D-fructose 1,6-bisphosphate, which is a key step in glucose metabolism (glycolysis). This enzyme is a tetramer that may be composed of different subunits encoded by distinct genes in different tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Chromosome

 21

Cytoband

 q22.3

Chromosome location (bp)

 44300051 - 44327376

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000141959 (version 83.38)

Entrez gene

 5211

UniProt

 P17858 (UniProt - Evidence at protein level)

neXtProt

 NX_P17858

Antibodypedia

 PFKL antibodies

PROTEIN BROWSER
PFKL-001
PFKL-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PFKL-001
ENSP00000269848
ENST00000349048
P17858 [Direct mapping]
ATP-dependent 6-phosphofructokinase, liver type
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Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003872 [6-phosphofructokinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005945 [6-phosphofructokinase complex]
GO:0005975 [carbohydrate metabolic process]
GO:0006002 [fructose 6-phosphate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006096 [glycolytic process]
GO:0009749 [response to glucose]
GO:0016020 [membrane]
GO:0019900 [kinase binding]
GO:0030388 [fructose 1,6-bisphosphate metabolic process]
GO:0042802 [identical protein binding]
GO:0044281 [small molecule metabolic process]
GO:0046676 [negative regulation of insulin secretion]
GO:0046872 [metal ion binding]
GO:0048029 [monosaccharide binding]
GO:0051259 [protein oligomerization]
GO:0051289 [protein homotetramerization]
GO:0061615 [glycolytic process through fructose-6-phosphate]
GO:0061621 [canonical glycolysis]
GO:0070061 [fructose binding]
GO:0070062 [extracellular exosome]
GO:0070095 [fructose-6-phosphate binding]
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 780 aa
85 kDa 		No 0
PFKL-201
ENSP00000486076
ENST00000628044
F8WEU2 [Direct mapping]
ATP-dependent 6-phosphofructokinase, liver type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 42 aa
4.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.