Expression of IFNAR1 in cancer - Summary

CANCER ATLAS

Gene description

Interferon (alpha, beta and omega) receptor 1

Protein class

Cancer-related genes, FDA approved drug targets, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA018015	HPA029226

GENE INFORMATION
Gene name	IFNAR1 (HGNC Symbol)
Synonyms	IFNAR, IFRC
Description	Interferon (alpha, beta and omega) receptor 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. [provided by RefSeq, Jul 2008]
Chromosome	21
Cytoband	q22.11
Chromosome location (bp)	33324477 - 33359862
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000142166 (version 83.38)
Entrez gene	3454
UniProt	P17181 (UniProt - Evidence at protein level)
neXtProt	NX_P17181
Antibodypedia	IFNAR1 antibodies

PROTEIN BROWSER

IFNAR1-001	IFNAR1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IFNAR1-001 ENSP00000270139 ENST00000270139	P17181 [Direct mapping] Interferon alpha/beta receptor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004904 [interferon receptor activity] GO:0004905 [type I interferon receptor activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007259 [JAK-STAT cascade] GO:0009615 [response to virus] GO:0019221 [cytokine-mediated signaling pathway] GO:0032728 [positive regulation of interferon-beta production] GO:0032729 [positive regulation of interferon-gamma production] GO:0042110 [T cell activation] GO:0045351 [type I interferon biosynthetic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0050718 [positive regulation of interleukin-1 beta secretion] GO:0050730 [regulation of peptidyl-tyrosine phosphorylation] GO:0051607 [defense response to virus] GO:0060337 [type I interferon signaling pathway] GO:0060338 [regulation of type I interferon-mediated signaling pathway] Show all	557 aa 63.5 kDa	Yes	1
IFNAR1-003 ENSP00000400161 ENST00000442071	C9J114 [Direct mapping] Interferon alpha/beta receptor 1 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0019221 [cytokine-mediated signaling pathway] Show all	136 aa 15.4 kDa	Yes	0