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Most of the malignant cells showed moderate cytoplasmic and nuclear immunoreactivity. Several cases of renal cancers were strongly stained. Most testicular cancer along with several squamous and basal cell carcinomas were weakly stained or negative.
This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts specifically on histones and other chromatin-associated proteins and is involved in regulation of gene expression. The enzyme may act in association with other proteins or within multi-protein complexes and may play a role in cell type-specific functions and cell lineage specification. A related pseudogene is located on chromosome 9. [provided by RefSeq, Aug 2013]