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Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

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Score

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CARM1
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    TISSUE

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    CELL

  • CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

CARM1

Gene description

Coactivator-associated arginine methyltransferase 1

Protein class

Cancer-related genes
Enzymes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

General cytoplasmic and nuclear expression.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 1 antibody.
CAB032961
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

CARM1 (HGNC Symbol)

Synonyms

PRMT4

Description

Coactivator-associated arginine methyltransferase 1 (HGNC Symbol)

Entrez gene summary

This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts specifically on histones and other chromatin-associated proteins and is involved in regulation of gene expression. The enzyme may act in association with other proteins or within multi-protein complexes and may play a role in cell type-specific functions and cell lineage specification. A related pseudogene is located on chromosome 9. [provided by RefSeq, Aug 2013]

Chromosome

19

Cytoband

p13.2

Chromosome location (bp)

10871513 - 10923070

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000142453 (version 83.38)

Entrez gene

10498

UniProt

Q86X55 (UniProt - Evidence at protein level)

neXtProt

NX_Q86X55

Antibodypedia

CARM1 antibodies

PROTEIN BROWSER

CARM1-002
CARM1-003
CARM1-008
CARM1-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CARM1-002
ENSP00000325690
ENST00000327064
Q86X55 [Direct mapping]
Histone-arginine methyltransferase CARM1
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003420 [regulation of growth plate cartilage chondrocyte proliferation]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006479 [protein methylation]
GO:0007568 [aging]
GO:0008013 [beta-catenin binding]
GO:0008168 [methyltransferase activity]
GO:0008276 [protein methyltransferase activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0008469 [histone-arginine N-methyltransferase activity]
GO:0016032 [viral process]
GO:0016274 [protein-arginine N-methyltransferase activity]
GO:0016571 [histone methylation]
GO:0019919 [peptidyl-arginine methylation, to asymmetrical-dimethyl arginine]
GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity]
GO:0030518 [intracellular steroid hormone receptor signaling pathway]
GO:0030520 [intracellular estrogen receptor signaling pathway]
GO:0032091 [negative regulation of protein binding]
GO:0033146 [regulation of intracellular estrogen receptor signaling pathway]
GO:0034969 [histone arginine methylation]
GO:0034970 [histone H3-R2 methylation]
GO:0034971 [histone H3-R17 methylation]
GO:0035242 [protein-arginine omega-N asymmetric methyltransferase activity]
GO:0035642 [histone methyltransferase activity (H3-R17 specific)]
GO:0042054 [histone methyltransferase activity]
GO:0042803 [protein homodimerization activity]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0051591 [response to cAMP]
GO:0060350 [endochondral bone morphogenesis]
GO:0070577 [lysine-acetylated histone binding]
GO:0090575 [RNA polymerase II transcription factor complex]
GO:1902415 [regulation of mRNA binding]
GO:2000171 [negative regulation of dendrite development]
Show all
608 aa
65.9 kDa
Yes 0
CARM1-003
ENSP00000340934
ENST00000344150
Q86X55 [Direct mapping]
Histone-arginine methyltransferase CARM1
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006479 [protein methylation]
GO:0008013 [beta-catenin binding]
GO:0008168 [methyltransferase activity]
GO:0008276 [protein methyltransferase activity]
GO:0008469 [histone-arginine N-methyltransferase activity]
GO:0016032 [viral process]
GO:0016274 [protein-arginine N-methyltransferase activity]
GO:0016571 [histone methylation]
GO:0019919 [peptidyl-arginine methylation, to asymmetrical-dimethyl arginine]
GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity]
GO:0033146 [regulation of intracellular estrogen receptor signaling pathway]
GO:0034970 [histone H3-R2 methylation]
GO:0034971 [histone H3-R17 methylation]
GO:0035242 [protein-arginine omega-N asymmetric methyltransferase activity]
GO:0035642 [histone methyltransferase activity (H3-R17 specific)]
GO:0042054 [histone methyltransferase activity]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0070577 [lysine-acetylated histone binding]
Show all
585 aa
63.5 kDa
Yes 0
CARM1-008
ENSP00000465417
ENST00000588947
K7EK20 [Direct mapping]
Histone-arginine methyltransferase CARM1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0019919 [peptidyl-arginine methylation, to asymmetrical-dimethyl arginine]
GO:0035242 [protein-arginine omega-N asymmetric methyltransferase activity]
Show all
120 aa
12.5 kDa
Yes 0
CARM1-010
ENSP00000467761
ENST00000586298
K7EQB9 [Direct mapping]
Histone-arginine methyltransferase CARM1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0019919 [peptidyl-arginine methylation, to asymmetrical-dimethyl arginine]
GO:0035242 [protein-arginine omega-N asymmetric methyltransferase activity]
Show all
176 aa
18.2 kDa
No 0

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