Cell atlas - LMO4 - The Human Protein Atlas

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LMO4

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS CELL CYCLE

GENE/PROTEIN

Antibody validation

Dictionary
	Midbody ring
	Nucleoplasm

Human cell
	Microtubules
	Nucleoplasm

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GENERAL INFORMATION
Gene name	LMO4
Gene description	LIM domain only 4
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the midbody ring.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)
Additional location	In addition localized to the Midbody ring (approved)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by biological definition

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA045877 , HPA061638
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the midbody ring.

Main location

Nucleoplasm (supported)

Additional location

Midbody ring (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA045877	RT4	Nucleoplasm
	HPA045877	U-2 OS	Nucleus
	HPA045877	U-2 OS	Cytosol
	HPA045877	U-251 MG	Nucleoplasm
	HPA061638	SiHa	Nucleoplasm
	HPA061638	U-2 OS	Nucleoplasm
	HPA061638	U-2 OS	Midbody ring	Intensity	Intensity
	HPA061638	U-251 MG	Nucleoplasm

CELL CYCLE
Summary	Expression has cell cycle dependency according to biological definition

GENE INFORMATION
Gene name	LMO4
Synonyms
Description	LIM domain only 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a cysteine-rich protein that contains two LIM domains but lacks a DNA-binding homeodomain. The encoded protein may play a role as a transcriptional regulator or as an oncogene. [provided by RefSeq, Aug 2008]
Chromosome	1
Cytoband	p22.3
Chromosome location (bp)	87328468 - 87348923
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143013 (version 83.38)
Entrez gene	8543
UniProt	P61968 (UniProt - Evidence at protein level)
neXtProt	NX_P61968
Antibodypedia	LMO4 antibodies

PROTEIN BROWSER

LMO4-001	LMO4-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LMO4-001 ENSP00000359575 ENST00000370544	P61968 [Direct mapping] LIM domain transcription factor LMO4 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001158 [enhancer sequence-specific DNA binding] GO:0001843 [neural tube closure] GO:0003281 [ventricular septum development] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005667 [transcription factor complex] GO:0006366 [transcription from RNA polymerase II promoter] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0021514 [ventral spinal cord interneuron differentiation] GO:0021522 [spinal cord motor neuron differentiation] GO:0021527 [spinal cord association neuron differentiation] GO:0031333 [negative regulation of protein complex assembly] GO:0042659 [regulation of cell fate specification] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048538 [thymus development] GO:0050865 [regulation of cell activation] Show all	165 aa 18 kDa	No	0
LMO4-002 ENSP00000359573 ENST00000370542	P61968 [Direct mapping] LIM domain transcription factor LMO4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001843 [neural tube closure] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005667 [transcription factor complex] GO:0006366 [transcription from RNA polymerase II promoter] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] Show all	165 aa 18 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.