Expression of RIT1 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Ras-like without CAAX 1

Protein class

Cancer-related genes, Disease related genes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA053249

GENE INFORMATION
Gene name	RIT1 (HGNC Symbol)
Synonyms	MGC125864, MGC125865, RIBB, RIT, ROC1
Description	Ras-like without CAAX 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of a subfamily of Ras-related GTPases. The encoded protein is involved in regulating p38 MAPK-dependent signaling cascades related to cellular stress. This protein also cooperates with nerve growth factor to promote neuronal development and regeneration. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
Chromosome	1
Cytoband	q22
Chromosome location (bp)	155897808 - 155911404
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143622 (version 83.38)
Entrez gene	6016
UniProt	Q92963 (UniProt - Evidence at protein level)
neXtProt	NX_Q92963
Antibodypedia	RIT1 antibodies

PROTEIN BROWSER

RIT1-001	RIT1-002	RIT1-005	RIT1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RIT1-001 ENSP00000357306 ENST00000368323	Q92963 [Direct mapping] GTP-binding protein Rit1 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0006886 [intracellular protein transport] GO:0006913 [nucleocytoplasmic transport] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0048011 [neurotrophin TRK receptor signaling pathway] Show all	219 aa 25.1 kDa	No	0
RIT1-002 ENSP00000357305 ENST00000368322	Q92963 [Direct mapping] GTP-binding protein Rit1 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0006886 [intracellular protein transport] GO:0006913 [nucleocytoplasmic transport] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0048011 [neurotrophin TRK receptor signaling pathway] Show all	236 aa 27.1 kDa	No	0
RIT1-005 ENSP00000441950 ENST00000539040	Q92963 [Direct mapping] GTP-binding protein Rit1 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0048011 [neurotrophin TRK receptor signaling pathway] Show all	183 aa 21.6 kDa	No	0
RIT1-006 ENSP00000476612 ENST00000609492	V9GYC3 [Direct mapping] GTP-binding protein Rit1 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0015031 [protein transport] GO:0016020 [membrane] Show all	151 aa 17 kDa	No	0