Tissue expression of RIT1 - Summary - The Human Protein Atlas

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RIT1

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	RIT1
Gene description	Ras-like without CAAX 1
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues.

DATA RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Approved based on 1 antibody. HPA053249
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	RIT1 (HGNC Symbol)
Synonyms	MGC125864, MGC125865, RIBB, RIT, ROC1
Description	Ras-like without CAAX 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of a subfamily of Ras-related GTPases. The encoded protein is involved in regulating p38 MAPK-dependent signaling cascades related to cellular stress. This protein also cooperates with nerve growth factor to promote neuronal development and regeneration. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
Chromosome	1
Cytoband	q22
Chromosome location (bp)	155897808 - 155911404
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143622 (version 83.38)
Entrez gene	6016
UniProt	Q92963 (UniProt - Evidence at protein level)
neXtProt	NX_Q92963
Antibodypedia	RIT1 antibodies

PROTEIN BROWSER

RIT1-001	RIT1-002	RIT1-005	RIT1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RIT1-001 ENSP00000357306 ENST00000368323	Q92963 [Direct mapping] GTP-binding protein Rit1 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0006886 [intracellular protein transport] GO:0006913 [nucleocytoplasmic transport] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0048011 [neurotrophin TRK receptor signaling pathway] Show all	219 aa 25.1 kDa	No	0
RIT1-002 ENSP00000357305 ENST00000368322	Q92963 [Direct mapping] GTP-binding protein Rit1 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0006886 [intracellular protein transport] GO:0006913 [nucleocytoplasmic transport] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0048011 [neurotrophin TRK receptor signaling pathway] Show all	236 aa 27.1 kDa	No	0
RIT1-005 ENSP00000441950 ENST00000539040	Q92963 [Direct mapping] GTP-binding protein Rit1 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0048011 [neurotrophin TRK receptor signaling pathway] Show all	183 aa 21.6 kDa	No	0
RIT1-006 ENSP00000476612 ENST00000609492	V9GYC3 [Direct mapping] GTP-binding protein Rit1 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0015031 [protein transport] GO:0016020 [membrane] Show all	151 aa 17 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.