Cell atlas - REG3G - The Human Protein Atlas

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REG3G

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	REG3G
Gene description	Regenerating islet-derived 3 gamma
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Not detected
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA060705
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Not detected Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA060705	SH-SY5Y	Cytosol
	HPA060705	U-251 MG	No staining

GENE INFORMATION
Gene name	REG3G (HGNC Symbol)
Synonyms	LPPM429, PAP1B, UNQ429
Description	Regenerating islet-derived 3 gamma (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the regenerating islet-derived genes (REG)3 protein family. These proteins are secreted, C-type lectins with a carbohydrate recognition domain and N-terminal signal peptide. The protein encoded by this gene is an antimicrobial lectin with activity against Gram-positive bacteria. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Nov 2014]
Chromosome	2
Cytoband	p12
Chromosome location (bp)	79025686 - 79028505
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143954 (version 83.38)
Entrez gene	130120
UniProt	Q6UW15 (UniProt - Evidence at protein level)
neXtProt	NX_Q6UW15
Antibodypedia	REG3G antibodies

PROTEIN BROWSER

REG3G-001	REG3G-002	REG3G-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
REG3G-001 ENSP00000377475 ENST00000393897	Q6UW15 [Direct mapping] Regenerating islet-derived protein 3-gamma Regenerating islet-derived protein 3-gamma 16.5 kDa form Regenerating islet-derived protein 3-gamma 15 kDa form Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0006953 [acute-phase response] GO:0010838 [positive regulation of keratinocyte proliferation] GO:0030246 [carbohydrate binding] GO:0045617 [negative regulation of keratinocyte differentiation] GO:0050830 [defense response to Gram-positive bacterium] GO:0090303 [positive regulation of wound healing] Show all	175 aa 19.3 kDa	Yes	0
REG3G-002 ENSP00000272324 ENST00000272324	Q6UW15 [Direct mapping] Regenerating islet-derived protein 3-gamma Regenerating islet-derived protein 3-gamma 16.5 kDa form Regenerating islet-derived protein 3-gamma 15 kDa form Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0006953 [acute-phase response] GO:0010838 [positive regulation of keratinocyte proliferation] GO:0030246 [carbohydrate binding] GO:0045617 [negative regulation of keratinocyte differentiation] GO:0050830 [defense response to Gram-positive bacterium] GO:0090303 [positive regulation of wound healing] Show all	175 aa 19.3 kDa	Yes	0
REG3G-003 ENSP00000387105 ENST00000409471	Q6UW15 [Direct mapping] Regenerating islet-derived protein 3-gamma Regenerating islet-derived protein 3-gamma 16.5 kDa form Regenerating islet-derived protein 3-gamma 15 kDa form Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0006953 [acute-phase response] GO:0010838 [positive regulation of keratinocyte proliferation] GO:0030246 [carbohydrate binding] GO:0045617 [negative regulation of keratinocyte differentiation] GO:0050830 [defense response to Gram-positive bacterium] GO:0090303 [positive regulation of wound healing] Show all	129 aa 14.4 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.