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REG3G

GENERAL INFORMATION

Gene name

 REG3G

Gene description

 Regenerating islet-derived 3 gamma

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (epididymis, testis)
GTEx:Tissue enriched (pancreas)
FANTOM5:Group enriched (pancreas, testis)

Protein evidence

 Evidence at protein level

Protein expression

 Expression in a subset of cells in gastrointestinal tissues.

DATA RELIABILITY

Data reliability
description

 Caution, targets protein from more than one gene. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA047894 , HPA048334
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Small intestine

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (epididymis, testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (pancreas)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (pancreas, testis)

GENE INFORMATION

Gene name

 REG3G (HGNC Symbol)

Synonyms

 LPPM429, PAP1B, UNQ429

Description

 Regenerating islet-derived 3 gamma (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the regenerating islet-derived genes (REG)3 protein family. These proteins are secreted, C-type lectins with a carbohydrate recognition domain and N-terminal signal peptide. The protein encoded by this gene is an antimicrobial lectin with activity against Gram-positive bacteria. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Nov 2014]

Chromosome

 2

Cytoband

 p12

Chromosome location (bp)

 79025686 - 79028505

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143954 (version 83.38)

Entrez gene

 130120

UniProt

 Q6UW15 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6UW15

Antibodypedia

 REG3G antibodies

PROTEIN BROWSER
REG3G-001
REG3G-002
REG3G-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
REG3G-001
ENSP00000377475
ENST00000393897
Q6UW15 [Direct mapping]
Regenerating islet-derived protein 3-gamma Regenerating islet-derived protein 3-gamma 16.5 kDa form Regenerating islet-derived protein 3-gamma 15 kDa form
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0006953 [acute-phase response]
GO:0010838 [positive regulation of keratinocyte proliferation]
GO:0030246 [carbohydrate binding]
GO:0045617 [negative regulation of keratinocyte differentiation]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0090303 [positive regulation of wound healing]
Show all
 175 aa
19.3 kDa 		Yes 0
REG3G-002
ENSP00000272324
ENST00000272324
Q6UW15 [Direct mapping]
Regenerating islet-derived protein 3-gamma Regenerating islet-derived protein 3-gamma 16.5 kDa form Regenerating islet-derived protein 3-gamma 15 kDa form
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0006953 [acute-phase response]
GO:0010838 [positive regulation of keratinocyte proliferation]
GO:0030246 [carbohydrate binding]
GO:0045617 [negative regulation of keratinocyte differentiation]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0090303 [positive regulation of wound healing]
Show all
 175 aa
19.3 kDa 		Yes 0
REG3G-003
ENSP00000387105
ENST00000409471
Q6UW15 [Direct mapping]
Regenerating islet-derived protein 3-gamma Regenerating islet-derived protein 3-gamma 16.5 kDa form Regenerating islet-derived protein 3-gamma 15 kDa form
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0006953 [acute-phase response]
GO:0010838 [positive regulation of keratinocyte proliferation]
GO:0030246 [carbohydrate binding]
GO:0045617 [negative regulation of keratinocyte differentiation]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0090303 [positive regulation of wound healing]
Show all
 129 aa
14.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.