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Heat shock 60kDa protein 1 (chaperonin) (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Several pseudogenes have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13. [provided by RefSeq, Jun 2010]
Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001530 [lipopolysaccharide binding] GO:0001666 [response to hypoxia] GO:0002020 [protease binding] GO:0002039 [p53 binding] GO:0002236 [detection of misfolded protein] GO:0002368 [B cell cytokine production] GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0002842 [positive regulation of T cell mediated immune response to tumor cell] GO:0003688 [DNA replication origin binding] GO:0003697 [single-stranded DNA binding] GO:0003725 [double-stranded RNA binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005759 [mitochondrial matrix] GO:0005769 [early endosome] GO:0005791 [rough endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005905 [coated pit] GO:0006457 [protein folding] GO:0006458 ['de novo' protein folding] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0006986 [response to unfolded protein] GO:0009408 [response to heat] GO:0009409 [response to cold] GO:0009986 [cell surface] GO:0010033 [response to organic substance] GO:0014070 [response to organic cyclic compound] GO:0016020 [membrane] GO:0016032 [viral process] GO:0016887 [ATPase activity] GO:0019907 [cyclin-dependent protein kinase activating kinase holoenzyme complex] GO:0030061 [mitochondrial crista] GO:0030135 [coated vesicle] GO:0030141 [secretory granule] GO:0031625 [ubiquitin protein ligase binding] GO:0032403 [protein complex binding] GO:0032496 [response to lipopolysaccharide] GO:0032727 [positive regulation of interferon-alpha production] GO:0032729 [positive regulation of interferon-gamma production] GO:0032733 [positive regulation of interleukin-10 production] GO:0032735 [positive regulation of interleukin-12 production] GO:0032755 [positive regulation of interleukin-6 production] GO:0033198 [response to ATP] GO:0042026 [protein refolding] GO:0042100 [B cell proliferation] GO:0042110 [T cell activation] GO:0042113 [B cell activation] GO:0042220 [response to cocaine] GO:0042493 [response to drug] GO:0042542 [response to hydrogen peroxide] GO:0042588 [zymogen granule] GO:0043032 [positive regulation of macrophage activation] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043209 [myelin sheath] GO:0043231 [intracellular membrane-bounded organelle] GO:0043234 [protein complex] GO:0043524 [negative regulation of neuron apoptotic process] GO:0043559 [insulin binding] GO:0043627 [response to estrogen] GO:0044822 [poly(A) RNA binding] GO:0045121 [membrane raft] GO:0046696 [lipopolysaccharide receptor complex] GO:0046982 [protein heterodimerization activity] GO:0048291 [isotype switching to IgG isotypes] GO:0050729 [positive regulation of inflammatory response] GO:0050821 [protein stabilization] GO:0050870 [positive regulation of T cell activation] GO:0051082 [unfolded protein binding] GO:0051085 [chaperone mediated protein folding requiring cofactor] GO:0051087 [chaperone binding] GO:0051131 [chaperone-mediated protein complex assembly] GO:0051604 [protein maturation] GO:0051787 [misfolded protein binding] GO:0070062 [extracellular exosome]
Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001530 [lipopolysaccharide binding] GO:0002039 [p53 binding] GO:0002368 [B cell cytokine production] GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0002842 [positive regulation of T cell mediated immune response to tumor cell] GO:0003688 [DNA replication origin binding] GO:0003697 [single-stranded DNA binding] GO:0003725 [double-stranded RNA binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005759 [mitochondrial matrix] GO:0005769 [early endosome] GO:0005829 [cytosol] GO:0005905 [coated pit] GO:0006457 [protein folding] GO:0006458 ['de novo' protein folding] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0006986 [response to unfolded protein] GO:0009409 [response to cold] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016032 [viral process] GO:0016887 [ATPase activity] GO:0019907 [cyclin-dependent protein kinase activating kinase holoenzyme complex] GO:0030135 [coated vesicle] GO:0030141 [secretory granule] GO:0031625 [ubiquitin protein ligase binding] GO:0032727 [positive regulation of interferon-alpha production] GO:0032729 [positive regulation of interferon-gamma production] GO:0032733 [positive regulation of interleukin-10 production] GO:0032735 [positive regulation of interleukin-12 production] GO:0032755 [positive regulation of interleukin-6 production] GO:0042026 [protein refolding] GO:0042100 [B cell proliferation] GO:0042110 [T cell activation] GO:0042113 [B cell activation] GO:0043032 [positive regulation of macrophage activation] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043234 [protein complex] GO:0044822 [poly(A) RNA binding] GO:0046696 [lipopolysaccharide receptor complex] GO:0048291 [isotype switching to IgG isotypes] GO:0050821 [protein stabilization] GO:0050870 [positive regulation of T cell activation] GO:0051082 [unfolded protein binding] GO:0051087 [chaperone binding] GO:0051131 [chaperone-mediated protein complex assembly] GO:0051604 [protein maturation] GO:0070062 [extracellular exosome]