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HSPD1
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

HSPD1

Gene description

Heat shock 60kDa protein 1 (chaperonin)

Protein class

Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

8
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Granular cytoplasmic expression in most cell types.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 3 antibodies.
HPA001523 , CAB002775 , CAB072816
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical
N/ACerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin02004006008001,000TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin0100200300400500RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina02004006008001,000Tags Per Million

GENE INFORMATION

Gene name

HSPD1 (HGNC Symbol)

Synonyms

GroEL, HSP60, SPG13

Description

Heat shock 60kDa protein 1 (chaperonin) (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Several pseudogenes have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13. [provided by RefSeq, Jun 2010]

Chromosome

2

Cytoband

q33.1

Chromosome location (bp)

197486581 - 197516737

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000144381 (version 83.38)

Entrez gene

3329

UniProt

P10809 (UniProt - Evidence at protein level)

neXtProt

NX_P10809

Antibodypedia

HSPD1 antibodies

PROTEIN BROWSER

HSPD1-001
HSPD1-006
HSPD1-009
HSPD1-010
HSPD1-011
HSPD1-012
HSPD1-013
HSPD1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HSPD1-001
ENSP00000373620
ENST00000388968
P10809 [Direct mapping]
60 kDa heat shock protein, mitochondrial
A0A024R3X4 [Target identity:100%; Query identity:100%]
Heat shock 60kDa protein 1 (Chaperonin), isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001530 [lipopolysaccharide binding]
GO:0001666 [response to hypoxia]
GO:0002020 [protease binding]
GO:0002039 [p53 binding]
GO:0002236 [detection of misfolded protein]
GO:0002368 [B cell cytokine production]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002842 [positive regulation of T cell mediated immune response to tumor cell]
GO:0003688 [DNA replication origin binding]
GO:0003697 [single-stranded DNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0005769 [early endosome]
GO:0005791 [rough endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005905 [coated pit]
GO:0006457 [protein folding]
GO:0006458 ['de novo' protein folding]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006986 [response to unfolded protein]
GO:0009408 [response to heat]
GO:0009409 [response to cold]
GO:0009986 [cell surface]
GO:0010033 [response to organic substance]
GO:0014070 [response to organic cyclic compound]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016887 [ATPase activity]
GO:0019907 [cyclin-dependent protein kinase activating kinase holoenzyme complex]
GO:0030061 [mitochondrial crista]
GO:0030135 [coated vesicle]
GO:0030141 [secretory granule]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032403 [protein complex binding]
GO:0032496 [response to lipopolysaccharide]
GO:0032727 [positive regulation of interferon-alpha production]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032733 [positive regulation of interleukin-10 production]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0033198 [response to ATP]
GO:0042026 [protein refolding]
GO:0042100 [B cell proliferation]
GO:0042110 [T cell activation]
GO:0042113 [B cell activation]
GO:0042220 [response to cocaine]
GO:0042493 [response to drug]
GO:0042542 [response to hydrogen peroxide]
GO:0042588 [zymogen granule]
GO:0043032 [positive regulation of macrophage activation]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043209 [myelin sheath]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043234 [protein complex]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043559 [insulin binding]
GO:0043627 [response to estrogen]
GO:0044822 [poly(A) RNA binding]
GO:0045121 [membrane raft]
GO:0046696 [lipopolysaccharide receptor complex]
GO:0046982 [protein heterodimerization activity]
GO:0048291 [isotype switching to IgG isotypes]
GO:0050729 [positive regulation of inflammatory response]
GO:0050821 [protein stabilization]
GO:0050870 [positive regulation of T cell activation]
GO:0051082 [unfolded protein binding]
GO:0051085 [chaperone mediated protein folding requiring cofactor]
GO:0051087 [chaperone binding]
GO:0051131 [chaperone-mediated protein complex assembly]
GO:0051604 [protein maturation]
GO:0051787 [misfolded protein binding]
GO:0070062 [extracellular exosome]
Show all
573 aa
61.1 kDa
No 0
HSPD1-006
ENSP00000412717
ENST00000452200
E7EXB4 [Direct mapping]
60 kDa heat shock protein, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
Show all
221 aa
23.8 kDa
No 0
HSPD1-009
ENSP00000414446
ENST00000426480
C9JL25 [Direct mapping]
60 kDa heat shock protein, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
Show all
175 aa
19.2 kDa
No 0
HSPD1-010
ENSP00000396460
ENST00000428204
C9JCQ4 [Direct mapping]
60 kDa heat shock protein, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
Show all
94 aa
10.3 kDa
No 0
HSPD1-011
ENSP00000402478
ENST00000439605
C9JL19 [Direct mapping]
60 kDa heat shock protein, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
Show all
83 aa
9 kDa
No 0
HSPD1-012
ENSP00000412227
ENST00000418022
C9J0S9 [Direct mapping]
60 kDa heat shock protein, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
Show all
58 aa
6.4 kDa
No 0
HSPD1-013
ENSP00000393670
ENST00000430176
E7ESH4 [Direct mapping]
60 kDa heat shock protein, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
Show all
234 aa
25.2 kDa
No 0
HSPD1-201
ENSP00000340019
ENST00000345042
P10809 [Direct mapping]
60 kDa heat shock protein, mitochondrial
A0A024R3X4 [Target identity:100%; Query identity:100%]
Heat shock 60kDa protein 1 (Chaperonin), isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001530 [lipopolysaccharide binding]
GO:0002039 [p53 binding]
GO:0002368 [B cell cytokine production]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002842 [positive regulation of T cell mediated immune response to tumor cell]
GO:0003688 [DNA replication origin binding]
GO:0003697 [single-stranded DNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0005769 [early endosome]
GO:0005829 [cytosol]
GO:0005905 [coated pit]
GO:0006457 [protein folding]
GO:0006458 ['de novo' protein folding]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006986 [response to unfolded protein]
GO:0009409 [response to cold]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016887 [ATPase activity]
GO:0019907 [cyclin-dependent protein kinase activating kinase holoenzyme complex]
GO:0030135 [coated vesicle]
GO:0030141 [secretory granule]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032727 [positive regulation of interferon-alpha production]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032733 [positive regulation of interleukin-10 production]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0042026 [protein refolding]
GO:0042100 [B cell proliferation]
GO:0042110 [T cell activation]
GO:0042113 [B cell activation]
GO:0043032 [positive regulation of macrophage activation]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043234 [protein complex]
GO:0044822 [poly(A) RNA binding]
GO:0046696 [lipopolysaccharide receptor complex]
GO:0048291 [isotype switching to IgG isotypes]
GO:0050821 [protein stabilization]
GO:0050870 [positive regulation of T cell activation]
GO:0051082 [unfolded protein binding]
GO:0051087 [chaperone binding]
GO:0051131 [chaperone-mediated protein complex assembly]
GO:0051604 [protein maturation]
GO:0070062 [extracellular exosome]
Show all
573 aa
61.1 kDa
No 0

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