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SLIT2
  • TISSUE

  • CELL

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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

SLIT2

Gene description

Slit guidance ligand 2

Protein class

Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Intracellular,Membrane,Secreted

Number of transcripts

9
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Mixed
GTEx:Mixed
FANTOM5:Mixed

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY

Data reliability
description

RNA-based expert annotation gave inconclusive results. Pending retesting. Antibody staining not consistent with RNA expression data.

Reliability score

Uncertain based on 3 antibodies.
HPA019511 , HPA023088 , CAB007590
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
N/A
Cerebral cortex
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Thyroid gland
N/A
Parathyroid gland
N/A
Adrenal gland
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Bone marrow
N/A
Lymph node
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Heart muscle
N/A
Skeletal muscle
N/A
Smooth muscle
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Gallbladder
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Salivary gland
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Small intestine
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
Prostate
N/A
Seminal vesicle
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
Endometrium
N/A
Fallopian tube
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Adipose tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW

RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin01020304050TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin0510152025RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina05101520Tags Per Million

GENE INFORMATION

Gene name

SLIT2 (HGNC Symbol)

Synonyms

SLIL3, Slit-2

Description

Slit guidance ligand 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the slit family of secreted glycoproteins, which are ligands for the Robo family of immunoglobulin receptors. Slit proteins play highly conserved roles in axon guidance and neuronal migration and may also have functions during other cell migration processes including leukocyte migration. Members of the slit family are characterized by an N-terminal signal peptide, four leucine-rich repeats, nine epidermal growth factor repeats, and a C-terminal cysteine knot. Proteolytic processing of this protein gives rise to an N-terminal fragment that contains the four leucine-rich repeats and five epidermal growth factor repeats and a C-terminal fragment that contains four epidermal growth factor repeats and the cysteine knot. Both full length and cleaved proteins are secreted extracellularly and can function in axon repulsion as well as other specific processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Chromosome

4

Cytoband

p15.31

Chromosome location (bp)

20253260 - 20620561

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000145147 (version 83.38)

Entrez gene

9353

UniProt

O94813 (UniProt - Evidence at protein level)

neXtProt

NX_O94813

Antibodypedia

SLIT2 antibodies

PROTEIN BROWSER

SLIT2-001
SLIT2-002
SLIT2-003
SLIT2-004
SLIT2-006
SLIT2-010
SLIT2-011
SLIT2-012
SLIT2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SLIT2-001
ENSP00000422591
ENST00000504154
O94813 [Direct mapping]
Slit homolog 2 protein Slit homolog 2 protein N-product Slit homolog 2 protein C-product
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001656 [metanephros development]
GO:0001657 [ureteric bud development]
GO:0001701 [in utero embryonic development]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0002042 [cell migration involved in sprouting angiogenesis]
GO:0002689 [negative regulation of leukocyte chemotaxis]
GO:0005095 [GTPase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007409 [axonogenesis]
GO:0007411 [axon guidance]
GO:0007420 [brain development]
GO:0008045 [motor neuron axon guidance]
GO:0008201 [heparin binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0009986 [cell surface]
GO:0010593 [negative regulation of lamellipodium assembly]
GO:0010596 [negative regulation of endothelial cell migration]
GO:0010629 [negative regulation of gene expression]
GO:0014912 [negative regulation of smooth muscle cell migration]
GO:0016020 [membrane]
GO:0016337 [single organismal cell-cell adhesion]
GO:0021510 [spinal cord development]
GO:0021772 [olfactory bulb development]
GO:0021836 [chemorepulsion involved in postnatal olfactory bulb interneuron migration]
GO:0021972 [corticospinal neuron axon guidance through spinal cord]
GO:0022029 [telencephalon cell migration]
GO:0030308 [negative regulation of cell growth]
GO:0030336 [negative regulation of cell migration]
GO:0030517 [negative regulation of axon extension]
GO:0030837 [negative regulation of actin filament polymerization]
GO:0031290 [retinal ganglion cell axon guidance]
GO:0031667 [response to nutrient levels]
GO:0032870 [cellular response to hormone stimulus]
GO:0033563 [dorsal/ventral axon guidance]
GO:0034260 [negative regulation of GTPase activity]
GO:0035385 [Roundabout signaling pathway]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043065 [positive regulation of apoptotic process]
GO:0043116 [negative regulation of vascular permeability]
GO:0043237 [laminin-1 binding]
GO:0043394 [proteoglycan binding]
GO:0043395 [heparan sulfate proteoglycan binding]
GO:0045499 [chemorepellent activity]
GO:0048495 [Roundabout binding]
GO:0048754 [branching morphogenesis of an epithelial tube]
GO:0048812 [neuron projection morphogenesis]
GO:0048846 [axon extension involved in axon guidance]
GO:0050728 [negative regulation of inflammatory response]
GO:0050772 [positive regulation of axonogenesis]
GO:0050919 [negative chemotaxis]
GO:0050929 [induction of negative chemotaxis]
GO:0051058 [negative regulation of small GTPase mediated signal transduction]
GO:0051414 [response to cortisol]
GO:0060603 [mammary gland duct morphogenesis]
GO:0060763 [mammary duct terminal end bud growth]
GO:0061364 [apoptotic process involved in luteolysis]
GO:0070062 [extracellular exosome]
GO:0070100 [negative regulation of chemokine-mediated signaling pathway]
GO:0071504 [cellular response to heparin]
GO:0071672 [negative regulation of smooth muscle cell chemotaxis]
GO:0071676 [negative regulation of mononuclear cell migration]
GO:0090024 [negative regulation of neutrophil chemotaxis]
GO:0090027 [negative regulation of monocyte chemotaxis]
GO:0090260 [negative regulation of retinal ganglion cell axon guidance]
GO:0090288 [negative regulation of cellular response to growth factor stimulus]
Show all
1529 aa
169.9 kDa
Yes 0
SLIT2-002
ENSP00000427548
ENST00000503823
O94813 [Direct mapping]
Slit homolog 2 protein Slit homolog 2 protein N-product Slit homolog 2 protein C-product
A0A0A6YYB8 [Direct mapping]
Slit homolog 2 protein
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001657 [ureteric bud development]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0002042 [cell migration involved in sprouting angiogenesis]
GO:0002689 [negative regulation of leukocyte chemotaxis]
GO:0005095 [GTPase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007411 [axon guidance]
GO:0008045 [motor neuron axon guidance]
GO:0008201 [heparin binding]
GO:0009986 [cell surface]
GO:0010593 [negative regulation of lamellipodium assembly]
GO:0010596 [negative regulation of endothelial cell migration]
GO:0014912 [negative regulation of smooth muscle cell migration]
GO:0016020 [membrane]
GO:0021836 [chemorepulsion involved in postnatal olfactory bulb interneuron migration]
GO:0021972 [corticospinal neuron axon guidance through spinal cord]
GO:0030308 [negative regulation of cell growth]
GO:0030336 [negative regulation of cell migration]
GO:0030837 [negative regulation of actin filament polymerization]
GO:0031290 [retinal ganglion cell axon guidance]
GO:0032870 [cellular response to hormone stimulus]
GO:0034260 [negative regulation of GTPase activity]
GO:0035385 [Roundabout signaling pathway]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043065 [positive regulation of apoptotic process]
GO:0043116 [negative regulation of vascular permeability]
GO:0043237 [laminin-1 binding]
GO:0043394 [proteoglycan binding]
GO:0048495 [Roundabout binding]
GO:0048754 [branching morphogenesis of an epithelial tube]
GO:0048846 [axon extension involved in axon guidance]
GO:0050772 [positive regulation of axonogenesis]
GO:0050919 [negative chemotaxis]
GO:0050929 [induction of negative chemotaxis]
GO:0051058 [negative regulation of small GTPase mediated signal transduction]
GO:0051414 [response to cortisol]
GO:0061364 [apoptotic process involved in luteolysis]
GO:0070062 [extracellular exosome]
GO:0070100 [negative regulation of chemokine-mediated signaling pathway]
GO:0071504 [cellular response to heparin]
GO:0071672 [negative regulation of smooth muscle cell chemotaxis]
GO:0071676 [negative regulation of mononuclear cell migration]
GO:0090024 [negative regulation of neutrophil chemotaxis]
GO:0090027 [negative regulation of monocyte chemotaxis]
GO:0090260 [negative regulation of retinal ganglion cell axon guidance]
GO:0090288 [negative regulation of cellular response to growth factor stimulus]
Show all
1521 aa
168.9 kDa
Yes 0
SLIT2-003
ENSP00000422261
ENST00000503837
O94813 [Direct mapping]
Slit homolog 2 protein Slit homolog 2 protein N-product Slit homolog 2 protein C-product
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001657 [ureteric bud development]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0002042 [cell migration involved in sprouting angiogenesis]
GO:0002689 [negative regulation of leukocyte chemotaxis]
GO:0005095 [GTPase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007411 [axon guidance]
GO:0008045 [motor neuron axon guidance]
GO:0008201 [heparin binding]
GO:0009986 [cell surface]
GO:0010593 [negative regulation of lamellipodium assembly]
GO:0010596 [negative regulation of endothelial cell migration]
GO:0014912 [negative regulation of smooth muscle cell migration]
GO:0016020 [membrane]
GO:0021836 [chemorepulsion involved in postnatal olfactory bulb interneuron migration]
GO:0021972 [corticospinal neuron axon guidance through spinal cord]
GO:0030308 [negative regulation of cell growth]
GO:0030336 [negative regulation of cell migration]
GO:0030837 [negative regulation of actin filament polymerization]
GO:0031290 [retinal ganglion cell axon guidance]
GO:0032870 [cellular response to hormone stimulus]
GO:0034260 [negative regulation of GTPase activity]
GO:0035385 [Roundabout signaling pathway]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043065 [positive regulation of apoptotic process]
GO:0043116 [negative regulation of vascular permeability]
GO:0043237 [laminin-1 binding]
GO:0043394 [proteoglycan binding]
GO:0048495 [Roundabout binding]
GO:0048754 [branching morphogenesis of an epithelial tube]
GO:0048846 [axon extension involved in axon guidance]
GO:0050772 [positive regulation of axonogenesis]
GO:0050919 [negative chemotaxis]
GO:0050929 [induction of negative chemotaxis]
GO:0051058 [negative regulation of small GTPase mediated signal transduction]
GO:0051414 [response to cortisol]
GO:0061364 [apoptotic process involved in luteolysis]
GO:0070062 [extracellular exosome]
GO:0070100 [negative regulation of chemokine-mediated signaling pathway]
GO:0071504 [cellular response to heparin]
GO:0071672 [negative regulation of smooth muscle cell chemotaxis]
GO:0071676 [negative regulation of mononuclear cell migration]
GO:0090024 [negative regulation of neutrophil chemotaxis]
GO:0090027 [negative regulation of monocyte chemotaxis]
GO:0090260 [negative regulation of retinal ganglion cell axon guidance]
GO:0090288 [negative regulation of cellular response to growth factor stimulus]
Show all
1525 aa
169.4 kDa
Yes 0
SLIT2-004
ENSP00000273739
ENST00000273739
X6R3P0 [Direct mapping]
Slit homolog 2 protein
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
Show all
1542 aa
171.3 kDa
Yes 0
SLIT2-006
ENSP00000426356
ENST00000508824
E9PCX4 [Direct mapping]
Slit homolog 2 protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
146 aa
16.7 kDa
No 0
SLIT2-010
ENSP00000425609
ENST00000509941
H0Y9Z6 [Direct mapping]
Slit homolog 2 protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
Show all
196 aa
21.7 kDa
No 1
SLIT2-011
ENSP00000423179
ENST00000512993
H0Y968 [Direct mapping]
Slit homolog 2 protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
82 aa
8.5 kDa
No 0
SLIT2-012
ENSP00000421975
ENST00000511508
F5H0U4 [Direct mapping]
Slit homolog 2 protein
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
212 aa
23.1 kDa
No 0
SLIT2-201
ENSP00000482129
ENST00000622093
A0A087WYV5 [Direct mapping]
Slit homolog 2 protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
Show all
1439 aa
160 kDa
No 0

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