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CCNA2

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GENERAL INFORMATION

Gene name

 CCNA2

Gene description

 Cyclin A2

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the cytosol & nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (validated), Cytosol (validated)

Single-cell variation

 Single-cell variation in protein expression observed.

GFP

 The location(s) are Validated based on analysis of GFP-tagged protein.

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
CAB000114 , HPA020626
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ASSAYS
RNA expression
Human cells
GFP

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the cytosol & nucleoplasm.

Main location

 Nucleoplasm (validated), Cytosol (validated)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB000114 A-431 Nucleoplasm Intensity
CAB000114 U-2 OS Nucleoplasm Spatial
Cytosol Spatial
CAB000114 U-251 MG Nucleoplasm Intensity
HPA020626 A-431 Nucleoplasm Spatial
Cytosol Spatial
HPA020626 RH-30 Nucleoplasm Spatial
Cytosol Spatial
HPA020626 U-2 OS Nucleoplasm Spatial
Cytosol Spatial

GFP

Antibody

 HPA020626

Validation

N-terminal tag
BAC cell line: 5335
Validated: Antibody staining overlaps with GFP tagged protein

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

BAC id

Tag

Location antibody staining

Location tagged protein
HPA020626 HeLa 5335 N-terminal Nucleoplasm, Cytosol Nucleoplasm, Cytosol
HPA020626 HeLa Normal - Nucleoplasm, Cytosol -

GENE INFORMATION

Gene name

 CCNA2 (HGNC Symbol)

Synonyms

 CCN1, CCNA

Description

 Cyclin A2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 q27

Chromosome location (bp)

 121816444 - 121823933

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000145386 (version 83.38)

Entrez gene

 890

UniProt

 P20248 (UniProt - Evidence at protein level)

neXtProt

 NX_P20248

Antibodypedia

 CCNA2 antibodies

PROTEIN BROWSER
CCNA2-001
CCNA2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CCNA2-001
ENSP00000274026
ENST00000274026
P20248 [Direct mapping]
Cyclin-A2
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   SPOCTOPUS predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0001939 [female pronucleus]
GO:0001940 [male pronucleus]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0007067 [mitotic nuclear division]
GO:0007095 [mitotic G2 DNA damage checkpoint]
GO:0007265 [Ras protein signal transduction]
GO:0016032 [viral process]
GO:0019901 [protein kinase binding]
GO:0031100 [organ regeneration]
GO:0032355 [response to estradiol]
GO:0033762 [response to glucagon]
GO:0036120 [cellular response to platelet-derived growth factor stimulus]
GO:0044320 [cellular response to leptin stimulus]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0051301 [cell division]
GO:0071314 [cellular response to cocaine]
GO:0071373 [cellular response to luteinizing hormone stimulus]
GO:0071392 [cellular response to estradiol stimulus]
GO:0071407 [cellular response to organic cyclic compound]
GO:0071456 [cellular response to hypoxia]
GO:0071732 [cellular response to nitric oxide]
GO:0090102 [cochlea development]
GO:1990314 [cellular response to insulin-like growth factor stimulus]
Show all
 432 aa
48.6 kDa 		No 0
CCNA2-201
ENSP00000481380
ENST00000618014
P20248 [Direct mapping]
Cyclin-A2
Show all
   SPOCTOPUS predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0007067 [mitotic nuclear division]
GO:0007095 [mitotic G2 DNA damage checkpoint]
GO:0007265 [Ras protein signal transduction]
GO:0016032 [viral process]
GO:0051301 [cell division]
Show all
 432 aa
48.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.