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CCNA2

GENERAL INFORMATION

Gene name

 CCNA2

Gene description

 Cyclin A2

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Tissue enhanced (appendix, tonsil)

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in a varying fraction of cells in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending reevalution.

Reliability score

 Approved based on 2 antibodies.
HPA020626 , CAB000114
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin051015202530TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin0246810RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (appendix, tonsil)
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina010203040Tags Per Million

GENE INFORMATION

Gene name

 CCNA2 (HGNC Symbol)

Synonyms

 CCN1, CCNA

Description

 Cyclin A2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 q27

Chromosome location (bp)

 121816444 - 121823933

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000145386 (version 83.38)

Entrez gene

 890

UniProt

 P20248 (UniProt - Evidence at protein level)

neXtProt

 NX_P20248

Antibodypedia

 CCNA2 antibodies

PROTEIN BROWSER
CCNA2-001
CCNA2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CCNA2-001
ENSP00000274026
ENST00000274026
P20248 [Direct mapping]
Cyclin-A2
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   SPOCTOPUS predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0001939 [female pronucleus]
GO:0001940 [male pronucleus]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0007067 [mitotic nuclear division]
GO:0007095 [mitotic G2 DNA damage checkpoint]
GO:0007265 [Ras protein signal transduction]
GO:0016032 [viral process]
GO:0019901 [protein kinase binding]
GO:0031100 [organ regeneration]
GO:0032355 [response to estradiol]
GO:0033762 [response to glucagon]
GO:0036120 [cellular response to platelet-derived growth factor stimulus]
GO:0044320 [cellular response to leptin stimulus]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0051301 [cell division]
GO:0071314 [cellular response to cocaine]
GO:0071373 [cellular response to luteinizing hormone stimulus]
GO:0071392 [cellular response to estradiol stimulus]
GO:0071407 [cellular response to organic cyclic compound]
GO:0071456 [cellular response to hypoxia]
GO:0071732 [cellular response to nitric oxide]
GO:0090102 [cochlea development]
GO:1990314 [cellular response to insulin-like growth factor stimulus]
Show all
 432 aa
48.6 kDa 		No 0
CCNA2-201
ENSP00000481380
ENST00000618014
P20248 [Direct mapping]
Cyclin-A2
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   SPOCTOPUS predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0007067 [mitotic nuclear division]
GO:0007095 [mitotic G2 DNA damage checkpoint]
GO:0007265 [Ras protein signal transduction]
GO:0016032 [viral process]
GO:0051301 [cell division]
Show all
 432 aa
48.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.