Expression of RARS2 in cancer - Summary

CANCER ATLAS

Gene description

Arginyl-tRNA synthetase 2, mitochondrial

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Glioma

STAINING SUMMARY

HPA039987	HPA042645

GENE INFORMATION
Gene name	RARS2 (HGNC Symbol)
Synonyms	DALRD2, dJ382I10.6, MGC14993, MGC23778, PRO1992, RARSL
Description	Arginyl-tRNA synthetase 2, mitochondrial (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is an arginyl-tRNA synthetase that is found in the mitochondrial matrix. Defects in this gene are a cause of pontocerebellar hypoplasia type 6 (PCH6). [provided by RefSeq, Oct 2008]
Chromosome	6
Cytoband	q15
Chromosome location (bp)	87514378 - 87590003
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000146282 (version 83.38)
Entrez gene	57038
UniProt	Q5T160 (UniProt - Evidence at protein level)
neXtProt	NX_Q5T160
Antibodypedia	RARS2 antibodies

PROTEIN BROWSER

RARS2-001	RARS2-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RARS2-001 ENSP00000358549 ENST00000369536	Q5T160 [Direct mapping] Probable arginine--tRNA ligase, mitochondrial Show all	Enzymes ENZYME proteins Ligase SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0004812 [aminoacyl-tRNA ligase activity] GO:0004814 [arginine-tRNA ligase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006420 [arginyl-tRNA aminoacylation] GO:0010467 [gene expression] GO:0032543 [mitochondrial translation] GO:0044822 [poly(A) RNA binding] Show all	578 aa 65.5 kDa	No	0
RARS2-004 ENSP00000389656 ENST00000451155	H0Y450 [Direct mapping] Probable arginine--tRNA ligase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0004812 [aminoacyl-tRNA ligase activity] GO:0004814 [arginine-tRNA ligase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006420 [arginyl-tRNA aminoacylation] GO:0032543 [mitochondrial translation] Show all	206 aa 23.2 kDa	No	0