Cell atlas - RARS2 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	RARS2
Gene description	Arginyl-tRNA synthetase 2, mitochondrial
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol. In addition localized to the nuclear bodies.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)
Additional location	In addition localized to the Nuclear bodies (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA042645
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol. In addition localized to the nuclear bodies.

Main location

Cytosol (approved)

Additional location

Nuclear bodies (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA042645	A-431	Cytosol
HPA042645	U-2 OS	Nuclear bodies
HPA042645	U-2 OS	Cytosol
HPA042645	U-251 MG	Cytosol

MOUSE CELLS

Main location

Not available

Mouse gene

ENSMUSG00000028292 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA042645	NIH 3T3	Cytosol

GENE INFORMATION
Gene name	RARS2 (HGNC Symbol)
Synonyms	DALRD2, dJ382I10.6, MGC14993, MGC23778, PRO1992, RARSL
Description	Arginyl-tRNA synthetase 2, mitochondrial (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is an arginyl-tRNA synthetase that is found in the mitochondrial matrix. Defects in this gene are a cause of pontocerebellar hypoplasia type 6 (PCH6). [provided by RefSeq, Oct 2008]
Chromosome	6
Cytoband	q15
Chromosome location (bp)	87514378 - 87590003
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000146282 (version 83.38)
Entrez gene	57038
UniProt	Q5T160 (UniProt - Evidence at protein level)
neXtProt	NX_Q5T160
Antibodypedia	RARS2 antibodies

PROTEIN BROWSER

RARS2-001	RARS2-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RARS2-001 ENSP00000358549 ENST00000369536	Q5T160 [Direct mapping] Probable arginine--tRNA ligase, mitochondrial Show all	Enzymes ENZYME proteins Ligase SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0004812 [aminoacyl-tRNA ligase activity] GO:0004814 [arginine-tRNA ligase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006420 [arginyl-tRNA aminoacylation] GO:0010467 [gene expression] GO:0032543 [mitochondrial translation] GO:0044822 [poly(A) RNA binding] Show all	578 aa 65.5 kDa	No	0
RARS2-004 ENSP00000389656 ENST00000451155	H0Y450 [Direct mapping] Probable arginine--tRNA ligase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0004812 [aminoacyl-tRNA ligase activity] GO:0004814 [arginine-tRNA ligase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006420 [arginyl-tRNA aminoacylation] GO:0032543 [mitochondrial translation] Show all	206 aa 23.2 kDa	No	0