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Most of the malignant cells showed weak to moderate positivity. A few cases of malignant lymphomas expressed strong staining. Most cases of renal cancers were negative.
GENE INFORMATION
Gene name
RSPO3 (HGNC Symbol)
Synonyms
FLJ14440, THSD2
Description
R-spondin 3 (HGNC Symbol)
Entrez gene summary
This gene belongs to the R-spondin family. The encoded protein plays a role in the regulation of Wnt (wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development, cell growth and disease pathogenesis. Genome-wide association studies suggest a correlation of this gene with bone mineral density and risk of fracture. This gene may be involved in tumor development. [provided by RefSeq, Jul 2013]
