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RSPO3

GENERAL INFORMATION

Gene name

 RSPO3

Gene description

 R-spondin 3

Protein class

 Cancer-related genes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (endometrium, smooth muscle)
GTEx:Tissue enhanced (endometrium)
FANTOM5:Tissue enhanced (endometrium)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several different cell types, including endothelial cells.

DATA RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA029957
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (endometrium, smooth muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (endometrium)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (endometrium)

GENE INFORMATION

Gene name

 RSPO3 (HGNC Symbol)

Synonyms

 FLJ14440, THSD2

Description

 R-spondin 3 (HGNC Symbol)

Entrez gene summary

 This gene belongs to the R-spondin family. The encoded protein plays a role in the regulation of Wnt (wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development, cell growth and disease pathogenesis. Genome-wide association studies suggest a correlation of this gene with bone mineral density and risk of fracture. This gene may be involved in tumor development. [provided by RefSeq, Jul 2013]

Chromosome

 6

Cytoband

 q22.33

Chromosome location (bp)

 127118604 - 127197765

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000146374 (version 83.38)

Entrez gene

 84870

UniProt

 Q9BXY4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BXY4

Antibodypedia

 RSPO3 antibodies

PROTEIN BROWSER
RSPO3-002
RSPO3-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RSPO3-002
ENSP00000357300
ENST00000368317
Q9BXY4 [Direct mapping]
R-spondin-3
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   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
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GO:0001664 [G-protein coupled receptor binding]
GO:0005102 [receptor binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0016055 [Wnt signaling pathway]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
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 292 aa
33.2 kDa 		Yes 0
RSPO3-003
ENSP00000349131
ENST00000356698
Q9BXY4 [Direct mapping]
R-spondin-3
Show all
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Show all
GO:0001525 [angiogenesis]
GO:0001664 [G-protein coupled receptor binding]
GO:0005102 [receptor binding]
GO:0005109 [frizzled binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0008201 [heparin binding]
GO:0016055 [Wnt signaling pathway]
GO:0060670 [branching involved in labyrinthine layer morphogenesis]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
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 272 aa
30.9 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.