Cell atlas - RSPO3 - The Human Protein Atlas

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RSPO3

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	RSPO3
Gene description	R-spondin 3
Protein class	Cancer-related genes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (A549, U-138 MG, U-87 MG)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (A549, U-138 MG, U-87 MG) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	RSPO3 (HGNC Symbol)
Synonyms	FLJ14440, THSD2
Description	R-spondin 3 (HGNC Symbol)
Entrez gene summary	This gene belongs to the R-spondin family. The encoded protein plays a role in the regulation of Wnt (wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development, cell growth and disease pathogenesis. Genome-wide association studies suggest a correlation of this gene with bone mineral density and risk of fracture. This gene may be involved in tumor development. [provided by RefSeq, Jul 2013]
Chromosome	6
Cytoband	q22.33
Chromosome location (bp)	127118604 - 127197765
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000146374 (version 83.38)
Entrez gene	84870
UniProt	Q9BXY4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BXY4
Antibodypedia	RSPO3 antibodies

PROTEIN BROWSER

RSPO3-002	RSPO3-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RSPO3-002 ENSP00000357300 ENST00000368317	Q9BXY4 [Direct mapping] R-spondin-3 Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0001664 [G-protein coupled receptor binding] GO:0005102 [receptor binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0016055 [Wnt signaling pathway] GO:0090263 [positive regulation of canonical Wnt signaling pathway] Show all	292 aa 33.2 kDa	Yes	0
RSPO3-003 ENSP00000349131 ENST00000356698	Q9BXY4 [Direct mapping] R-spondin-3 Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0001525 [angiogenesis] GO:0001664 [G-protein coupled receptor binding] GO:0005102 [receptor binding] GO:0005109 [frizzled binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0008201 [heparin binding] GO:0016055 [Wnt signaling pathway] GO:0060670 [branching involved in labyrinthine layer morphogenesis] GO:0090263 [positive regulation of canonical Wnt signaling pathway] Show all	272 aa 30.9 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.