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TAF1

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GENERAL INFORMATION

Gene name

 TAF1

Gene description

 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa

Protein class

 Cancer-related genes
Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (validated)

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
HPA001075 , CAB016283
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoplasm.

Main location

 Nucleoplasm (validated)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA001075 A-431 Nucleoplasm
HPA001075 U-2 OS Nucleoplasm
HPA001075 U-251 MG Nucleoplasm
CAB016283 A-431 Nucleoplasm
CAB016283 U-2 OS Nucleoplasm
CAB016283 U-251 MG Nucleoplasm

GENE INFORMATION

Gene name

 TAF1 (HGNC Symbol)

Synonyms

 BA2R, CCG1, CCGS, DYT3, DYT3/TAF1, KAT4, NSCL2, TAF2A, TAFII250

Description

 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa (HGNC Symbol)

Entrez gene summary

 Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription initiation. This subunit contains two independent protein kinase domains at the N- and C-terminals, but also possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. Mutations in this gene result in Dystonia 3, torsion, X-linked, a dystonia-parkinsonism disorder. Alternative splicing of this gene results in multiple transcript variants. This gene is part of a complex transcription unit (TAF1/DYT3), wherein some transcript variants share exons with TAF1 as well as additional downstream DYT3 exons. [provided by RefSeq, Oct 2013]

Chromosome

 X

Cytoband

 q13.1

Chromosome location (bp)

 71366239 - 71532374

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000147133 (version 83.38)

Entrez gene

 6872

UniProt

 P21675 (UniProt - Evidence at protein level)

neXtProt

 NX_P21675

Antibodypedia

 TAF1 antibodies

PROTEIN BROWSER
TAF1-007
TAF1-008
TAF1-009
TAF1-017
TAF1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TAF1-007
ENSP00000421611
ENST00000463163
H0Y8N6 [Direct mapping]
Transcription initiation factor TFIID subunit 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 150 aa
17.8 kDa 		No 0
TAF1-008
ENSP00000276072
ENST00000276072
P21675 [Direct mapping]
Transcription initiation factor TFIID subunit 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005669 [transcription factor TFIID complex]
GO:0006352 [DNA-templated transcription, initiation]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007049 [cell cycle]
GO:0008134 [transcription factor binding]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0016573 [histone acetylation]
GO:0017025 [TBP-class protein binding]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046777 [protein autophosphorylation]
GO:0051123 [RNA polymerase II transcriptional preinitiation complex assembly]
GO:0060261 [positive regulation of transcription initiation from RNA polymerase II promoter]
GO:0070577 [lysine-acetylated histone binding]
GO:0071339 [MLL1 complex]
Show all
 1893 aa
214.7 kDa 		No 0
TAF1-009
ENSP00000362895
ENST00000373790
P21675 [Direct mapping]
Transcription initiation factor TFIID subunit 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005669 [transcription factor TFIID complex]
GO:0006352 [DNA-templated transcription, initiation]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007049 [cell cycle]
GO:0008134 [transcription factor binding]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0016573 [histone acetylation]
GO:0017025 [TBP-class protein binding]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046777 [protein autophosphorylation]
GO:0051123 [RNA polymerase II transcriptional preinitiation complex assembly]
GO:0060261 [positive regulation of transcription initiation from RNA polymerase II promoter]
GO:0070577 [lysine-acetylated histone binding]
GO:0071339 [MLL1 complex]
Show all
 1872 aa
212.7 kDa 		No 0
TAF1-017
ENSP00000424526
ENST00000483985
H0Y9L7 [Direct mapping]
Transcription initiation factor TFIID subunit 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
 279 aa
32.4 kDa 		No 0
TAF1-201
ENSP00000406549
ENST00000423759
P21675 [Direct mapping]
Transcription initiation factor TFIID subunit 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005669 [transcription factor TFIID complex]
GO:0006352 [DNA-templated transcription, initiation]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007049 [cell cycle]
GO:0008134 [transcription factor binding]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0016573 [histone acetylation]
GO:0017025 [TBP-class protein binding]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046777 [protein autophosphorylation]
GO:0051123 [RNA polymerase II transcriptional preinitiation complex assembly]
GO:0060261 [positive regulation of transcription initiation from RNA polymerase II promoter]
GO:0070577 [lysine-acetylated histone binding]
GO:0071339 [MLL1 complex]
Show all
 1895 aa
214.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.