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TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa (HGNC Symbol)
Entrez gene summary
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription initiation. This subunit contains two independent protein kinase domains at the N- and C-terminals, but also possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. Mutations in this gene result in Dystonia 3, torsion, X-linked, a dystonia-parkinsonism disorder. Alternative splicing of this gene results in multiple transcript variants. This gene is part of a complex transcription unit (TAF1/DYT3), wherein some transcript variants share exons with TAF1 as well as additional downstream DYT3 exons. [provided by RefSeq, Oct 2013]
Enzymes ENZYME proteins Transferases SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Transcription factors Other all-alpha-helical DNA-binding domains Cancer-related genes Mutational cancer driver genes Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002039 [p53 binding] GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0004402 [histone acetyltransferase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005669 [transcription factor TFIID complex] GO:0006352 [DNA-templated transcription, initiation] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006368 [transcription elongation from RNA polymerase II promoter] GO:0006974 [cellular response to DNA damage stimulus] GO:0007049 [cell cycle] GO:0008134 [transcription factor binding] GO:0010467 [gene expression] GO:0016032 [viral process] GO:0016573 [histone acetylation] GO:0017025 [TBP-class protein binding] GO:0018105 [peptidyl-serine phosphorylation] GO:0018107 [peptidyl-threonine phosphorylation] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046777 [protein autophosphorylation] GO:0051123 [RNA polymerase II transcriptional preinitiation complex assembly] GO:0060261 [positive regulation of transcription initiation from RNA polymerase II promoter] GO:0070577 [lysine-acetylated histone binding] GO:0071339 [MLL1 complex]
Enzymes ENZYME proteins Transferases SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Transcription factors Other all-alpha-helical DNA-binding domains Cancer-related genes Mutational cancer driver genes Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002039 [p53 binding] GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0004402 [histone acetyltransferase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005669 [transcription factor TFIID complex] GO:0006352 [DNA-templated transcription, initiation] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006368 [transcription elongation from RNA polymerase II promoter] GO:0006974 [cellular response to DNA damage stimulus] GO:0007049 [cell cycle] GO:0008134 [transcription factor binding] GO:0010467 [gene expression] GO:0016032 [viral process] GO:0016573 [histone acetylation] GO:0017025 [TBP-class protein binding] GO:0018105 [peptidyl-serine phosphorylation] GO:0018107 [peptidyl-threonine phosphorylation] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046777 [protein autophosphorylation] GO:0051123 [RNA polymerase II transcriptional preinitiation complex assembly] GO:0060261 [positive regulation of transcription initiation from RNA polymerase II promoter] GO:0070577 [lysine-acetylated histone binding] GO:0071339 [MLL1 complex]
Enzymes ENZYME proteins Transferases SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Transcription factors Other all-alpha-helical DNA-binding domains Cancer-related genes Mutational cancer driver genes Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002039 [p53 binding] GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0004402 [histone acetyltransferase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005669 [transcription factor TFIID complex] GO:0006352 [DNA-templated transcription, initiation] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006368 [transcription elongation from RNA polymerase II promoter] GO:0006974 [cellular response to DNA damage stimulus] GO:0007049 [cell cycle] GO:0008134 [transcription factor binding] GO:0010467 [gene expression] GO:0016032 [viral process] GO:0016573 [histone acetylation] GO:0017025 [TBP-class protein binding] GO:0018105 [peptidyl-serine phosphorylation] GO:0018107 [peptidyl-threonine phosphorylation] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046777 [protein autophosphorylation] GO:0051123 [RNA polymerase II transcriptional preinitiation complex assembly] GO:0060261 [positive regulation of transcription initiation from RNA polymerase II promoter] GO:0070577 [lysine-acetylated histone binding] GO:0071339 [MLL1 complex]
