Expression of WHSC1L1 in cancer - Summary

CANCER ATLAS

Gene description

Wolf-Hirschhorn syndrome candidate 1-like 1

Protein class

Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA005659	HPA018893	CAB013721

Tissue	Cancer staining	Protein expression of normal tissue
Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma

Tissue	Cancer staining	Protein expression of normal tissue
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary	Weak to moderate cytoplasmic staining was generally observed in malignant cells.

GENE INFORMATION
Gene name	WHSC1L1 (HGNC Symbol)
Synonyms	FLJ20353, NSD3
Description	Wolf-Hirschhorn syndrome candidate 1-like 1 (HGNC Symbol)
Entrez gene summary	This gene is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. This protein methylates histone H3 at lysine residues 4 and 27, which represses gene transcription. Two alternatively spliced variants have been described. [provided by RefSeq, May 2015]
Chromosome	8
Cytoband	p11.23
Chromosome location (bp)	38269697 - 38382272
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000147548 (version 83.38)
Entrez gene	54904
UniProt	Q9BZ95 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BZ95
Antibodypedia	WHSC1L1 antibodies

PROTEIN BROWSER

WHSC1L1-001	WHSC1L1-002	WHSC1L1-003	WHSC1L1-005	WHSC1L1-008	WHSC1L1-009	WHSC1L1-010	WHSC1L1-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
WHSC1L1-001 ENSP00000313983 ENST00000317025	Q9BZ95 [Direct mapping] Histone-lysine N-methyltransferase NSD3 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0016571 [histone methylation] GO:0018024 [histone-lysine N-methyltransferase activity] GO:0042800 [histone methyltransferase activity (H3-K4 specific)] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046976 [histone methyltransferase activity (H3-K27 specific)] GO:0051568 [histone H3-K4 methylation] GO:0070734 [histone H3-K27 methylation] Show all	1437 aa 161.6 kDa	No	0
WHSC1L1-002 ENSP00000313410 ENST00000316985	Q9BZ95 [Direct mapping] Histone-lysine N-methyltransferase NSD3 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0016571 [histone methylation] GO:0018024 [histone-lysine N-methyltransferase activity] Show all	645 aa 72.6 kDa	No	0
WHSC1L1-003 ENSP00000393284 ENST00000433384	Q9BZ95 [Direct mapping] Histone-lysine N-methyltransferase NSD3 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0016571 [histone methylation] GO:0018024 [histone-lysine N-methyltransferase activity] Show all	1388 aa 156.1 kDa	No	0
WHSC1L1-005 ENSP00000434730 ENST00000527502	Q9BZ95 [Direct mapping] Histone-lysine N-methyltransferase NSD3 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0016571 [histone methylation] GO:0018024 [histone-lysine N-methyltransferase activity] Show all	1426 aa 160.3 kDa	No	0
WHSC1L1-008 ENSP00000432544 ENST00000534155	E9PQ95 [Direct mapping] Histone-lysine N-methyltransferase NSD3 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		25 aa 2.8 kDa	No	0
WHSC1L1-009 ENSP00000435422 ENST00000529223	E9PKA2 [Direct mapping] Histone-lysine N-methyltransferase NSD3 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		282 aa 31.6 kDa	No	0
WHSC1L1-010 ENSP00000431598 ENST00000534539	E9PKL3 [Direct mapping] Histone-lysine N-methyltransferase NSD3 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		15 aa 1.7 kDa	No	0
WHSC1L1-011 ENSP00000435073 ENST00000528627	H0YE68 [Direct mapping] Histone-lysine N-methyltransferase NSD3 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		77 aa 8.6 kDa	No	0