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WHSC1L1
  • TISSUE

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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

WHSC1L1

Gene description

Wolf-Hirschhorn syndrome candidate 1-like 1

Protein class

Cancer-related genes
Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

8
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

Pending external verification.

Reliability score

Uncertain based on 3 antibodies.
HPA005659 , HPA018893 , CAB013721
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin01020304050TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin0246810RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina020406080100120Tags Per Million

GENE INFORMATION

Gene name

WHSC1L1 (HGNC Symbol)

Synonyms

FLJ20353, NSD3

Description

Wolf-Hirschhorn syndrome candidate 1-like 1 (HGNC Symbol)

Entrez gene summary

This gene is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. This protein methylates histone H3 at lysine residues 4 and 27, which represses gene transcription. Two alternatively spliced variants have been described. [provided by RefSeq, May 2015]

Chromosome

8

Cytoband

p11.23

Chromosome location (bp)

38269697 - 38382272

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000147548 (version 83.38)

Entrez gene

54904

UniProt

Q9BZ95 (UniProt - Evidence at protein level)

neXtProt

NX_Q9BZ95

Antibodypedia

WHSC1L1 antibodies

PROTEIN BROWSER

WHSC1L1-001
WHSC1L1-002
WHSC1L1-003
WHSC1L1-005
WHSC1L1-008
WHSC1L1-009
WHSC1L1-010
WHSC1L1-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

WHSC1L1-001
ENSP00000313983
ENST00000317025
Q9BZ95 [Direct mapping]
Histone-lysine N-methyltransferase NSD3
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0016571 [histone methylation]
GO:0018024 [histone-lysine N-methyltransferase activity]
GO:0042800 [histone methyltransferase activity (H3-K4 specific)]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046976 [histone methyltransferase activity (H3-K27 specific)]
GO:0051568 [histone H3-K4 methylation]
GO:0070734 [histone H3-K27 methylation]
Show all
1437 aa
161.6 kDa
No 0
WHSC1L1-002
ENSP00000313410
ENST00000316985
Q9BZ95 [Direct mapping]
Histone-lysine N-methyltransferase NSD3
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0016571 [histone methylation]
GO:0018024 [histone-lysine N-methyltransferase activity]
Show all
645 aa
72.6 kDa
No 0
WHSC1L1-003
ENSP00000393284
ENST00000433384
Q9BZ95 [Direct mapping]
Histone-lysine N-methyltransferase NSD3
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0016571 [histone methylation]
GO:0018024 [histone-lysine N-methyltransferase activity]
Show all
1388 aa
156.1 kDa
No 0
WHSC1L1-005
ENSP00000434730
ENST00000527502
Q9BZ95 [Direct mapping]
Histone-lysine N-methyltransferase NSD3
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0016571 [histone methylation]
GO:0018024 [histone-lysine N-methyltransferase activity]
Show all
1426 aa
160.3 kDa
No 0
WHSC1L1-008
ENSP00000432544
ENST00000534155
E9PQ95 [Direct mapping]
Histone-lysine N-methyltransferase NSD3
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
25 aa
2.8 kDa
No 0
WHSC1L1-009
ENSP00000435422
ENST00000529223
E9PKA2 [Direct mapping]
Histone-lysine N-methyltransferase NSD3
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
282 aa
31.6 kDa
No 0
WHSC1L1-010
ENSP00000431598
ENST00000534539
E9PKL3 [Direct mapping]
Histone-lysine N-methyltransferase NSD3
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
15 aa
1.7 kDa
No 0
WHSC1L1-011
ENSP00000435073
ENST00000528627
H0YE68 [Direct mapping]
Histone-lysine N-methyltransferase NSD3
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
77 aa
8.6 kDa
No 0

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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.