Cell atlas - WHSC1L1 - The Human Protein Atlas

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WHSC1L1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria
	Nucleoplasm

Human cell
	Mitochondria
	Nucleoplasm

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GENERAL INFORMATION
Gene name	WHSC1L1
Gene description	Wolf-Hirschhorn syndrome candidate 1-like 1
Protein class	Cancer-related genes Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the mitochondria. In addition localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (approved)
Additional location	In addition localized to the Nucleoplasm (supported)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA018893
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the mitochondria. In addition localized to the nucleoplasm.

Main location

Mitochondria (approved)

Additional location

Nucleoplasm (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA018893	A-431	Nucleoplasm
	HPA018893	A-431	Mitochondria
	HPA018893	U-251 MG	Nucleoplasm
	HPA018893	U-251 MG	Mitochondria

GENE INFORMATION
Gene name	WHSC1L1 (HGNC Symbol)
Synonyms	FLJ20353, NSD3
Description	Wolf-Hirschhorn syndrome candidate 1-like 1 (HGNC Symbol)
Entrez gene summary	This gene is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. This protein methylates histone H3 at lysine residues 4 and 27, which represses gene transcription. Two alternatively spliced variants have been described. [provided by RefSeq, May 2015]
Chromosome	8
Cytoband	p11.23
Chromosome location (bp)	38269697 - 38382272
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000147548 (version 83.38)
Entrez gene	54904
UniProt	Q9BZ95 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BZ95
Antibodypedia	WHSC1L1 antibodies

PROTEIN BROWSER

WHSC1L1-001	WHSC1L1-002	WHSC1L1-003	WHSC1L1-005	WHSC1L1-008	WHSC1L1-009	WHSC1L1-010	WHSC1L1-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
WHSC1L1-001 ENSP00000313983 ENST00000317025	Q9BZ95 [Direct mapping] Histone-lysine N-methyltransferase NSD3 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0016571 [histone methylation] GO:0018024 [histone-lysine N-methyltransferase activity] GO:0042800 [histone methyltransferase activity (H3-K4 specific)] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046976 [histone methyltransferase activity (H3-K27 specific)] GO:0051568 [histone H3-K4 methylation] GO:0070734 [histone H3-K27 methylation] Show all	1437 aa 161.6 kDa	No	0
WHSC1L1-002 ENSP00000313410 ENST00000316985	Q9BZ95 [Direct mapping] Histone-lysine N-methyltransferase NSD3 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0016571 [histone methylation] GO:0018024 [histone-lysine N-methyltransferase activity] Show all	645 aa 72.6 kDa	No	0
WHSC1L1-003 ENSP00000393284 ENST00000433384	Q9BZ95 [Direct mapping] Histone-lysine N-methyltransferase NSD3 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0016571 [histone methylation] GO:0018024 [histone-lysine N-methyltransferase activity] Show all	1388 aa 156.1 kDa	No	0
WHSC1L1-005 ENSP00000434730 ENST00000527502	Q9BZ95 [Direct mapping] Histone-lysine N-methyltransferase NSD3 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0016571 [histone methylation] GO:0018024 [histone-lysine N-methyltransferase activity] Show all	1426 aa 160.3 kDa	No	0
WHSC1L1-008 ENSP00000432544 ENST00000534155	E9PQ95 [Direct mapping] Histone-lysine N-methyltransferase NSD3 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		25 aa 2.8 kDa	No	0
WHSC1L1-009 ENSP00000435422 ENST00000529223	E9PKA2 [Direct mapping] Histone-lysine N-methyltransferase NSD3 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		282 aa 31.6 kDa	No	0
WHSC1L1-010 ENSP00000431598 ENST00000534539	E9PKL3 [Direct mapping] Histone-lysine N-methyltransferase NSD3 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		15 aa 1.7 kDa	No	0
WHSC1L1-011 ENSP00000435073 ENST00000528627	H0YE68 [Direct mapping] Histone-lysine N-methyltransferase NSD3 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		77 aa 8.6 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.