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CAMK2G
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

CAMK2G

Gene description

Calcium/calmodulin-dependent protein kinase II gamma

Protein class

Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

9
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression at variable levels in selected tissues, most abundant neuronal cells.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

Approved based on 3 antibodies.
HPA051783 , HPA051785 , HPA053973
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin020406080100120TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin01020304050RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina050100150200250Tags Per Million

GENE INFORMATION

Gene name

CAMK2G (HGNC Symbol)

Synonyms

CAMKG

Description

Calcium/calmodulin-dependent protein kinase II gamma (HGNC Symbol)

Entrez gene summary

The product of this gene is one of the four subunits of an enzyme which belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Many alternatively spliced transcripts encoding different isoforms have been described but the full-length nature of all the variants has not been determined.[provided by RefSeq, Mar 2011]

Chromosome

10

Cytoband

q22.2

Chromosome location (bp)

73812501 - 73874591

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000148660 (version 83.38)

Entrez gene

818

UniProt

Q13555 (UniProt - Evidence at protein level)

neXtProt

NX_Q13555

Antibodypedia

CAMK2G antibodies

PROTEIN BROWSER

CAMK2G-001
CAMK2G-002
CAMK2G-003
CAMK2G-004
CAMK2G-005
CAMK2G-010
CAMK2G-201
CAMK2G-202
CAMK2G-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CAMK2G-001
ENSP00000315599
ENST00000322635
Q13555 [Direct mapping]
Calcium/calmodulin-dependent protein kinase type II subunit gamma
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0004723 [calcium-dependent protein serine/threonine phosphatase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006470 [protein dephosphorylation]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0014733 [regulation of skeletal muscle adaptation]
GO:0016020 [membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030073 [insulin secretion]
GO:0030666 [endocytic vesicle membrane]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0034605 [cellular response to heat]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042803 [protein homodimerization activity]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051259 [protein oligomerization]
GO:0051924 [regulation of calcium ion transport]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:1900034 [regulation of cellular response to heat]
Show all
527 aa
59 kDa
No 1
CAMK2G-002
ENSP00000277853
ENST00000351293
Q13555 [Direct mapping]
Calcium/calmodulin-dependent protein kinase type II subunit gamma
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0004723 [calcium-dependent protein serine/threonine phosphatase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006470 [protein dephosphorylation]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0014733 [regulation of skeletal muscle adaptation]
GO:0016020 [membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030073 [insulin secretion]
GO:0030666 [endocytic vesicle membrane]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0034605 [cellular response to heat]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042803 [protein homodimerization activity]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051259 [protein oligomerization]
GO:0051924 [regulation of calcium ion transport]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:1900034 [regulation of cellular response to heat]
Show all
495 aa
56 kDa
No 1
CAMK2G-003
ENSP00000393784
ENST00000433289
Q8WU40 [Direct mapping]
CAMK2G protein; Calcium/calmodulin-dependent protein kinase type II subunit gamma
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
453 aa
50.9 kDa
No 1
CAMK2G-004
ENSP00000361851
ENST00000372765
Q5SWX3 [Direct mapping]
Calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma, isoform CRA_n; Calcium/calmodulin-dependent protein kinase type II subunit gamma
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
516 aa
57.8 kDa
No 1
CAMK2G-005
ENSP00000307082
ENST00000305762
Q13555 [Direct mapping]
Calcium/calmodulin-dependent protein kinase type II subunit gamma
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0004723 [calcium-dependent protein serine/threonine phosphatase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006470 [protein dephosphorylation]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0014733 [regulation of skeletal muscle adaptation]
GO:0016020 [membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030073 [insulin secretion]
GO:0030666 [endocytic vesicle membrane]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0034605 [cellular response to heat]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042803 [protein homodimerization activity]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051259 [protein oligomerization]
GO:0051924 [regulation of calcium ion transport]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:1900034 [regulation of cellular response to heat]
Show all
529 aa
59.6 kDa
No 1
CAMK2G-010
ENSP00000405561
ENST00000441192
H0Y6G2 [Direct mapping]
Calcium/calmodulin-dependent protein kinase type II subunit gamma
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
335 aa
36.9 kDa
No 0
CAMK2G-201
ENSP00000319060
ENST00000322680
Q13555 [Direct mapping]
Calcium/calmodulin-dependent protein kinase type II subunit gamma
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0004723 [calcium-dependent protein serine/threonine phosphatase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006470 [protein dephosphorylation]
GO:0006816 [calcium ion transport]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0014733 [regulation of skeletal muscle adaptation]
GO:0016020 [membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030073 [insulin secretion]
GO:0030666 [endocytic vesicle membrane]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0034605 [cellular response to heat]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042803 [protein homodimerization activity]
GO:0045087 [innate immune response]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051259 [protein oligomerization]
GO:0051924 [regulation of calcium ion transport]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0097481 [neuronal postsynaptic density]
GO:1900034 [regulation of cellular response to heat]
GO:1901897 [regulation of relaxation of cardiac muscle]
Show all
556 aa
62.2 kDa
No 1
CAMK2G-202
ENSP00000378243
ENST00000394762
A0A0A0MS52 [Direct mapping]
Calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma, isoform CRA_a; Calcium/calmodulin-dependent protein kinase type II subunit gamma
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
539 aa
60.2 kDa
No 1
CAMK2G-203
ENSP00000410298
ENST00000423381
A0A0A0MT11 [Direct mapping]
Calcium/calmodulin-dependent protein kinase type II subunit gamma
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
558 aa
62.6 kDa
No 1

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