Cell atlas - CAMK2G - The Human Protein Atlas

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CAMK2G

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cell Junctions
	Cytosol
	Plasma membrane

Human cell
	Cytosol
	Plasma Membrane

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GENERAL INFORMATION
Gene name	CAMK2G
Gene description	Calcium/calmodulin-dependent protein kinase II gamma
Protein class	Enzymes Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane & cell junctions. In addition localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved), Cell Junctions (approved)
Additional location	In addition localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 2 antibodies. HPA040656 , HPA051785
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane & cell junctions. In addition localized to the cytosol.

Main location

Plasma membrane (approved), Cell Junctions (approved)

Additional location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA040656	PC-3	Plasma membrane
	HPA040656	RT4	Cytosol
	HPA040656	U-2 OS	Plasma membrane
	HPA040656	U-2 OS	Cytosol
	HPA051785	A-431	No staining
	HPA051785	U-2 OS	Plasma membrane
	HPA051785	U-251 MG	Plasma membrane
	HPA051785	U-251 MG	Cell Junctions

GENE INFORMATION
Gene name	CAMK2G (HGNC Symbol)
Synonyms	CAMKG
Description	Calcium/calmodulin-dependent protein kinase II gamma (HGNC Symbol)
Entrez gene summary	The product of this gene is one of the four subunits of an enzyme which belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Many alternatively spliced transcripts encoding different isoforms have been described but the full-length nature of all the variants has not been determined.[provided by RefSeq, Mar 2011]
Chromosome	10
Cytoband	q22.2
Chromosome location (bp)	73812501 - 73874591
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000148660 (version 83.38)
Entrez gene	818
UniProt	Q13555 (UniProt - Evidence at protein level)
neXtProt	NX_Q13555
Antibodypedia	CAMK2G antibodies

PROTEIN BROWSER

CAMK2G-001	CAMK2G-002	CAMK2G-003	CAMK2G-004	CAMK2G-005	CAMK2G-010	CAMK2G-201	CAMK2G-202	CAMK2G-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CAMK2G-001 ENSP00000315599 ENST00000322635	Q13555 [Direct mapping] Calcium/calmodulin-dependent protein kinase type II subunit gamma Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0004672 [protein kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0004723 [calcium-dependent protein serine/threonine phosphatase activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0006470 [protein dephosphorylation] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007268 [synaptic transmission] GO:0007411 [axon guidance] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0014733 [regulation of skeletal muscle adaptation] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0030073 [insulin secretion] GO:0030666 [endocytic vesicle membrane] GO:0033017 [sarcoplasmic reticulum membrane] GO:0034605 [cellular response to heat] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042803 [protein homodimerization activity] GO:0045087 [innate immune response] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0051259 [protein oligomerization] GO:0051924 [regulation of calcium ion transport] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:1900034 [regulation of cellular response to heat] Show all	527 aa 59 kDa	No	1
CAMK2G-002 ENSP00000277853 ENST00000351293	Q13555 [Direct mapping] Calcium/calmodulin-dependent protein kinase type II subunit gamma Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0004672 [protein kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0004723 [calcium-dependent protein serine/threonine phosphatase activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0006470 [protein dephosphorylation] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007268 [synaptic transmission] GO:0007411 [axon guidance] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0014733 [regulation of skeletal muscle adaptation] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0030073 [insulin secretion] GO:0030666 [endocytic vesicle membrane] GO:0033017 [sarcoplasmic reticulum membrane] GO:0034605 [cellular response to heat] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042803 [protein homodimerization activity] GO:0045087 [innate immune response] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0051259 [protein oligomerization] GO:0051924 [regulation of calcium ion transport] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:1900034 [regulation of cellular response to heat] Show all	495 aa 56 kDa	No	1
CAMK2G-003 ENSP00000393784 ENST00000433289	Q8WU40 [Direct mapping] CAMK2G protein; Calcium/calmodulin-dependent protein kinase type II subunit gamma Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	453 aa 50.9 kDa	No	1
CAMK2G-004 ENSP00000361851 ENST00000372765	Q5SWX3 [Direct mapping] Calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma, isoform CRA_n; Calcium/calmodulin-dependent protein kinase type II subunit gamma Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	516 aa 57.8 kDa	No	1
CAMK2G-005 ENSP00000307082 ENST00000305762	Q13555 [Direct mapping] Calcium/calmodulin-dependent protein kinase type II subunit gamma Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0004672 [protein kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0004723 [calcium-dependent protein serine/threonine phosphatase activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0006470 [protein dephosphorylation] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007268 [synaptic transmission] GO:0007411 [axon guidance] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0014733 [regulation of skeletal muscle adaptation] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0030073 [insulin secretion] GO:0030666 [endocytic vesicle membrane] GO:0033017 [sarcoplasmic reticulum membrane] GO:0034605 [cellular response to heat] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042803 [protein homodimerization activity] GO:0045087 [innate immune response] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0051259 [protein oligomerization] GO:0051924 [regulation of calcium ion transport] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:1900034 [regulation of cellular response to heat] Show all	529 aa 59.6 kDa	No	1
CAMK2G-010 ENSP00000405561 ENST00000441192	H0Y6G2 [Direct mapping] Calcium/calmodulin-dependent protein kinase type II subunit gamma Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	335 aa 36.9 kDa	No	0
CAMK2G-201 ENSP00000319060 ENST00000322680	Q13555 [Direct mapping] Calcium/calmodulin-dependent protein kinase type II subunit gamma Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0004723 [calcium-dependent protein serine/threonine phosphatase activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0006470 [protein dephosphorylation] GO:0006816 [calcium ion transport] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007268 [synaptic transmission] GO:0007411 [axon guidance] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0014733 [regulation of skeletal muscle adaptation] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0030073 [insulin secretion] GO:0030666 [endocytic vesicle membrane] GO:0033017 [sarcoplasmic reticulum membrane] GO:0034605 [cellular response to heat] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042803 [protein homodimerization activity] GO:0045087 [innate immune response] GO:0046777 [protein autophosphorylation] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0051259 [protein oligomerization] GO:0051924 [regulation of calcium ion transport] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0097481 [neuronal postsynaptic density] GO:1900034 [regulation of cellular response to heat] GO:1901897 [regulation of relaxation of cardiac muscle] Show all	556 aa 62.2 kDa	No	1
CAMK2G-202 ENSP00000378243 ENST00000394762	A0A0A0MS52 [Direct mapping] Calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma, isoform CRA_a; Calcium/calmodulin-dependent protein kinase type II subunit gamma Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	539 aa 60.2 kDa	No	1
CAMK2G-203 ENSP00000410298 ENST00000423381	A0A0A0MT11 [Direct mapping] Calcium/calmodulin-dependent protein kinase type II subunit gamma Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	558 aa 62.6 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.