Fields »
ABOUT
HELP
BLOG
ADAM12

GENERAL INFORMATION

Gene name

 ADAM12

Gene description

 ADAM metallopeptidase domain 12

Protein class

 Enzymes
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (placenta)
GTEx:Tissue enhanced (ovary)
FANTOM5:Tissue enriched (placenta)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous expression in placental trophoblasts.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 3 antibodies.
HPA030866 , HPA030867 , HPA030868
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (placenta)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (ovary)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (placenta)

GENE INFORMATION

Gene name

 ADAM12 (HGNC Symbol)

Synonyms

 MCMPMltna, MLTN

Description

 ADAM metallopeptidase domain 12 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form. [provided by RefSeq, Jan 2014]

Chromosome

 10

Cytoband

 q26.2

Chromosome location (bp)

 126012381 - 126388455

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000148848 (version 83.38)

Entrez gene

 8038

UniProt

 O43184 (UniProt - Evidence at protein level)

neXtProt

 NX_O43184

Antibodypedia

 ADAM12 antibodies

PROTEIN BROWSER
ADAM12-001
ADAM12-002
ADAM12-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADAM12-001
ENSP00000357668
ENST00000368679
O43184 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 12
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0007155 [cell adhesion]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007520 [myoblast fusion]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0016021 [integral component of membrane]
GO:0017124 [SH3 domain binding]
Show all
 909 aa
99.5 kDa 		Yes 1
ADAM12-002
ENSP00000357665
ENST00000368676
O43184 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 12
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0007155 [cell adhesion]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007520 [myoblast fusion]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0016021 [integral component of membrane]
GO:0017124 [SH3 domain binding]
Show all
 738 aa
80.4 kDa 		Yes 0
ADAM12-003
ENSP00000391268
ENST00000448723
Q5JRP2 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 12
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0006508 [proteolysis]
GO:0008270 [zinc ion binding]
Show all
 278 aa
31.1 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.