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Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit, where it forms part of the domain where translation is initiated. The protein belongs to the S3P family of ribosomal proteins. Studies of the mouse and rat proteins have demonstrated that the protein has an extraribosomal role as an endonuclease involved in the repair of UV-induced DNA damage. The protein appears to be located in both the cytoplasm and nucleus but not in the nucleolus. Higher levels of expression of this gene in colon adenocarcinomas and adenomatous polyps compared to adjacent normal colonic mucosa have been observed. This gene is co-transcribed with the small nucleolar RNA genes U15A and U15B, which are located in its first and fifth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Enzymes ENZYME proteins Lyases Ribosomal proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay] GO:0003677 [DNA binding] GO:0003684 [damaged DNA binding] GO:0003723 [RNA binding] GO:0003729 [mRNA binding] GO:0003735 [structural constituent of ribosome] GO:0003906 [DNA-(apurinic or apyrimidinic site) lyase activity] GO:0004520 [endodeoxyribonuclease activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005743 [mitochondrial inner membrane] GO:0005759 [mitochondrial matrix] GO:0005829 [cytosol] GO:0005840 [ribosome] GO:0005844 [polysome] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006281 [DNA repair] GO:0006351 [transcription, DNA-templated] GO:0006412 [translation] GO:0006413 [translational initiation] GO:0006414 [translational elongation] GO:0006415 [translational termination] GO:0006614 [SRP-dependent cotranslational protein targeting to membrane] GO:0006974 [cellular response to DNA damage stimulus] GO:0006979 [response to oxidative stress] GO:0007059 [chromosome segregation] GO:0007067 [mitotic nuclear division] GO:0008017 [microtubule binding] GO:0008134 [transcription factor binding] GO:0008534 [oxidized purine nucleobase lesion DNA N-glycosylase activity] GO:0010467 [gene expression] GO:0010628 [positive regulation of gene expression] GO:0015631 [tubulin binding] GO:0015935 [small ribosomal subunit] GO:0016020 [membrane] GO:0016032 [viral process] GO:0017148 [negative regulation of translation] GO:0019058 [viral life cycle] GO:0019083 [viral transcription] GO:0019899 [enzyme binding] GO:0019900 [kinase binding] GO:0019901 [protein kinase binding] GO:0022627 [cytosolic small ribosomal subunit] GO:0030529 [ribonucleoprotein complex] GO:0030544 [Hsp70 protein binding] GO:0031116 [positive regulation of microtubule polymerization] GO:0031397 [negative regulation of protein ubiquitination] GO:0032079 [positive regulation of endodeoxyribonuclease activity] GO:0032183 [SUMO binding] GO:0032357 [oxidized purine DNA binding] GO:0032358 [oxidized pyrimidine DNA binding] GO:0032587 [ruffle membrane] GO:0042769 [DNA damage response, detection of DNA damage] GO:0042981 [regulation of apoptotic process] GO:0043507 [positive regulation of JUN kinase activity] GO:0044267 [cellular protein metabolic process] GO:0044390 [ubiquitin-like protein conjugating enzyme binding] GO:0044822 [poly(A) RNA binding] GO:0045738 [negative regulation of DNA repair] GO:0045739 [positive regulation of DNA repair] GO:0051018 [protein kinase A binding] GO:0051059 [NF-kappaB binding] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051225 [spindle assembly] GO:0051301 [cell division] GO:0051536 [iron-sulfur cluster binding] GO:0051879 [Hsp90 protein binding] GO:0061481 [response to TNF agonist] GO:0070062 [extracellular exosome] GO:0070181 [small ribosomal subunit rRNA binding] GO:0070301 [cellular response to hydrogen peroxide] GO:0071159 [NF-kappaB complex] GO:0072686 [mitotic spindle] GO:0097100 [supercoiled DNA binding] GO:1901224 [positive regulation of NIK/NF-kappaB signaling] GO:1902231 [positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage] GO:1902546 [positive regulation of DNA N-glycosylase activity] GO:2001235 [positive regulation of apoptotic signaling pathway] GO:2001272 [positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis]
Enzymes ENZYME proteins Lyases Ribosomal proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay] GO:0003677 [DNA binding] GO:0003684 [damaged DNA binding] GO:0003723 [RNA binding] GO:0003729 [mRNA binding] GO:0003735 [structural constituent of ribosome] GO:0003906 [DNA-(apurinic or apyrimidinic site) lyase activity] GO:0004520 [endodeoxyribonuclease activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005743 [mitochondrial inner membrane] GO:0005759 [mitochondrial matrix] GO:0005829 [cytosol] GO:0005840 [ribosome] GO:0005844 [polysome] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006281 [DNA repair] GO:0006351 [transcription, DNA-templated] GO:0006412 [translation] GO:0006413 [translational initiation] GO:0006414 [translational elongation] GO:0006415 [translational termination] GO:0006614 [SRP-dependent cotranslational protein targeting to membrane] GO:0006974 [cellular response to DNA damage stimulus] GO:0006979 [response to oxidative stress] GO:0007059 [chromosome segregation] GO:0007067 [mitotic nuclear division] GO:0008017 [microtubule binding] GO:0008134 [transcription factor binding] GO:0008534 [oxidized purine nucleobase lesion DNA N-glycosylase activity] GO:0010467 [gene expression] GO:0010628 [positive regulation of gene expression] GO:0015631 [tubulin binding] GO:0015935 [small ribosomal subunit] GO:0016020 [membrane] GO:0016032 [viral process] GO:0017148 [negative regulation of translation] GO:0019058 [viral life cycle] GO:0019083 [viral transcription] GO:0019899 [enzyme binding] GO:0019900 [kinase binding] GO:0019901 [protein kinase binding] GO:0022627 [cytosolic small ribosomal subunit] GO:0030529 [ribonucleoprotein complex] GO:0030544 [Hsp70 protein binding] GO:0031116 [positive regulation of microtubule polymerization] GO:0031397 [negative regulation of protein ubiquitination] GO:0032079 [positive regulation of endodeoxyribonuclease activity] GO:0032183 [SUMO binding] GO:0032357 [oxidized purine DNA binding] GO:0032358 [oxidized pyrimidine DNA binding] GO:0032587 [ruffle membrane] GO:0042769 [DNA damage response, detection of DNA damage] GO:0042981 [regulation of apoptotic process] GO:0043507 [positive regulation of JUN kinase activity] GO:0044267 [cellular protein metabolic process] GO:0044390 [ubiquitin-like protein conjugating enzyme binding] GO:0044822 [poly(A) RNA binding] GO:0045738 [negative regulation of DNA repair] GO:0045739 [positive regulation of DNA repair] GO:0051018 [protein kinase A binding] GO:0051059 [NF-kappaB binding] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051225 [spindle assembly] GO:0051301 [cell division] GO:0051536 [iron-sulfur cluster binding] GO:0051879 [Hsp90 protein binding] GO:0061481 [response to TNF agonist] GO:0070062 [extracellular exosome] GO:0070181 [small ribosomal subunit rRNA binding] GO:0070301 [cellular response to hydrogen peroxide] GO:0071159 [NF-kappaB complex] GO:0072686 [mitotic spindle] GO:0097100 [supercoiled DNA binding] GO:1901224 [positive regulation of NIK/NF-kappaB signaling] GO:1902231 [positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage] GO:1902546 [positive regulation of DNA N-glycosylase activity] GO:2001235 [positive regulation of apoptotic signaling pathway] GO:2001272 [positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis]