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Malignant tissues exhibited moderate to strong nuclear immunoreactivity. Cases of prostate and testicular cancers were weakly stained negative.
GENE INFORMATION
Gene name
MTA2 (HGNC Symbol)
Synonyms
MTA1-L1, MTA1L1
Description
Metastasis associated 1 family, member 2 (HGNC Symbol)
Entrez gene summary
This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. [provided by RefSeq, May 2011]
O94776 [Direct mapping] Metastasis-associated protein MTA2 A0A024R534 [Target identity:100%; Query identity:100%] Metastasis associated 1 family, member 2, isoform CRA_a
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Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000118 [histone deacetylase complex] GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0000989 [transcription factor activity, transcription factor binding] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001103 [RNA polymerase II repressing transcription factor binding] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0004407 [histone deacetylase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0006306 [DNA methylation] GO:0006325 [chromatin organization] GO:0006333 [chromatin assembly or disassembly] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0010762 [regulation of fibroblast migration] GO:0016020 [membrane] GO:0016575 [histone deacetylation] GO:0016581 [NuRD complex] GO:0031492 [nucleosomal DNA binding] GO:0042826 [histone deacetylase binding] GO:0043044 [ATP-dependent chromatin remodeling] GO:0043234 [protein complex] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
