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MTA2

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GENERAL INFORMATION

Gene name

 MTA2

Gene description

 Metastasis associated 1 family, member 2

Protein class

 Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (validated)

siRNA

 The location(s) are Validated based on siRNA mediated gene silencing.

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
HPA006214 , CAB017522
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ASSAYS
RNA expression
Human cells
siRNA

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoplasm.

Main location

 Nucleoplasm (validated)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB017522 A-431 Nucleoplasm
CAB017522 U-2 OS Nucleoplasm
CAB017522 U-251 MG Nucleoplasm
HPA006214 A-431 Nucleoplasm
HPA006214 U-2 OS Nucleoplasm
HPA006214 U-251 MG Nucleoplasm

siRNA VALIDATION
 

Relative fluorescence intensity (RFI)

Antibody

 HPA006214

siRNA validation

 Validated: Significant downregulation > 25% by both siRNA:s.

Analysis performed in

 Nuclear region of segmented cells in 10x-images

siRNA 1

siRNA 2

RFI

 57%61%

p-value

 < 0.01< 0.01
 

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail 10x

Thumbnail 40x

Antibody

Sample

Cell line
HPA006214 siRNA 1 U-2 OS
HPA006214 siRNA 2 U-2 OS
HPA006214 scrambled U-2 OS

GENE INFORMATION

Gene name

 MTA2 (HGNC Symbol)

Synonyms

 MTA1-L1, MTA1L1

Description

 Metastasis associated 1 family, member 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. [provided by RefSeq, May 2011]

Chromosome

 11

Cytoband

 q12.3

Chromosome location (bp)

 62593214 - 62601840

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000149480 (version 83.38)

Entrez gene

 9219

UniProt

 O94776 (UniProt - Evidence at protein level)

neXtProt

 NX_O94776

Antibodypedia

 MTA2 antibodies

PROTEIN BROWSER
MTA2-001
MTA2-002
MTA2-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MTA2-001
ENSP00000278823
ENST00000278823
O94776 [Direct mapping]
Metastasis-associated protein MTA2
A0A024R534 [Target identity:100%; Query identity:100%]
Metastasis associated 1 family, member 2, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000118 [histone deacetylase complex]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0000989 [transcription factor activity, transcription factor binding]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001103 [RNA polymerase II repressing transcription factor binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004407 [histone deacetylase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0006306 [DNA methylation]
GO:0006325 [chromatin organization]
GO:0006333 [chromatin assembly or disassembly]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0010762 [regulation of fibroblast migration]
GO:0016020 [membrane]
GO:0016575 [histone deacetylation]
GO:0016581 [NuRD complex]
GO:0031492 [nucleosomal DNA binding]
GO:0042826 [histone deacetylase binding]
GO:0043044 [ATP-dependent chromatin remodeling]
GO:0043234 [protein complex]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 668 aa
75 kDa 		No 0
MTA2-002
ENSP00000431346
ENST00000524902
O94776 [Direct mapping]
Metastasis-associated protein MTA2
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000118 [histone deacetylase complex]
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001103 [RNA polymerase II repressing transcription factor binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0006325 [chromatin organization]
GO:0006333 [chromatin assembly or disassembly]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0016020 [membrane]
GO:0016581 [NuRD complex]
GO:0031492 [nucleosomal DNA binding]
GO:0043044 [ATP-dependent chromatin remodeling]
GO:0043234 [protein complex]
GO:0043565 [sequence-specific DNA binding]
Show all
 495 aa
55 kDa 		No 0
MTA2-003
ENSP00000431797
ENST00000527204
O94776 [Direct mapping]
Metastasis-associated protein MTA2
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000118 [histone deacetylase complex]
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001103 [RNA polymerase II repressing transcription factor binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0006325 [chromatin organization]
GO:0006333 [chromatin assembly or disassembly]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0016020 [membrane]
GO:0016581 [NuRD complex]
GO:0031492 [nucleosomal DNA binding]
GO:0043044 [ATP-dependent chromatin remodeling]
GO:0043234 [protein complex]
GO:0043565 [sequence-specific DNA binding]
Show all
 495 aa
55 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.