Fields »
ABOUT
HELP
BLOG
CDC42EP2

CANCER ATLAS

Gene description

 CDC42 effector protein (Rho GTPase binding) 2

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA038562

GENE INFORMATION

Gene name

 CDC42EP2 (HGNC Symbol)

Synonyms

 BORG1, CEP2

Description

 CDC42 effector protein (Rho GTPase binding) 2 (HGNC Symbol)

Entrez gene summary

 CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of CDC42. Coexpression of this protein with CDC42 suggested a role of this protein in actin filament assembly and cell shape control. [provided by RefSeq, Aug 2011]

Chromosome

 11

Cytoband

 q13.1

Chromosome location (bp)

 65314818 - 65322429

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000149798 (version 83.38)

Entrez gene

 10435

UniProt

 O14613 (UniProt - Evidence at protein level)

neXtProt

 NX_O14613

Antibodypedia

 CDC42EP2 antibodies

PROTEIN BROWSER
CDC42EP2-001
CDC42EP2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CDC42EP2-001
ENSP00000279249
ENST00000279249
O14613 [Direct mapping]
Cdc42 effector protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001515 [opioid peptide activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007015 [actin filament organization]
GO:0007266 [Rho protein signal transduction]
GO:0008360 [regulation of cell shape]
GO:0012505 [endomembrane system]
GO:0015630 [microtubule cytoskeleton]
GO:0016020 [membrane]
GO:0017049 [GTP-Rho binding]
GO:0030036 [actin cytoskeleton organization]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031274 [positive regulation of pseudopodium assembly]
GO:0031334 [positive regulation of protein complex assembly]
GO:0043547 [positive regulation of GTPase activity]
Show all
 210 aa
22.5 kDa 		No 0
CDC42EP2-002
ENSP00000431660
ENST00000533419
O14613 [Direct mapping]
Cdc42 effector protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007015 [actin filament organization]
GO:0007266 [Rho protein signal transduction]
GO:0008360 [regulation of cell shape]
GO:0012505 [endomembrane system]
GO:0015630 [microtubule cytoskeleton]
GO:0016020 [membrane]
GO:0017049 [GTP-Rho binding]
GO:0030036 [actin cytoskeleton organization]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031274 [positive regulation of pseudopodium assembly]
GO:0031334 [positive regulation of protein complex assembly]
GO:0043547 [positive regulation of GTPase activity]
Show all
 210 aa
22.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.