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CDC42EP2

GENERAL INFORMATION

Gene name

 CDC42EP2

Gene description

 CDC42 effector protein (Rho GTPase binding) 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissue.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA038562
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CDC42EP2 (HGNC Symbol)

Synonyms

 BORG1, CEP2

Description

 CDC42 effector protein (Rho GTPase binding) 2 (HGNC Symbol)

Entrez gene summary

 CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of CDC42. Coexpression of this protein with CDC42 suggested a role of this protein in actin filament assembly and cell shape control. [provided by RefSeq, Aug 2011]

Chromosome

 11

Cytoband

 q13.1

Chromosome location (bp)

 65314818 - 65322429

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000149798 (version 83.38)

Entrez gene

 10435

UniProt

 O14613 (UniProt - Evidence at protein level)

neXtProt

 NX_O14613

Antibodypedia

 CDC42EP2 antibodies

PROTEIN BROWSER
CDC42EP2-001
CDC42EP2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CDC42EP2-001
ENSP00000279249
ENST00000279249
O14613 [Direct mapping]
Cdc42 effector protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001515 [opioid peptide activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007015 [actin filament organization]
GO:0007266 [Rho protein signal transduction]
GO:0008360 [regulation of cell shape]
GO:0012505 [endomembrane system]
GO:0015630 [microtubule cytoskeleton]
GO:0016020 [membrane]
GO:0017049 [GTP-Rho binding]
GO:0030036 [actin cytoskeleton organization]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031274 [positive regulation of pseudopodium assembly]
GO:0031334 [positive regulation of protein complex assembly]
GO:0043547 [positive regulation of GTPase activity]
Show all
 210 aa
22.5 kDa 		No 0
CDC42EP2-002
ENSP00000431660
ENST00000533419
O14613 [Direct mapping]
Cdc42 effector protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007015 [actin filament organization]
GO:0007266 [Rho protein signal transduction]
GO:0008360 [regulation of cell shape]
GO:0012505 [endomembrane system]
GO:0015630 [microtubule cytoskeleton]
GO:0016020 [membrane]
GO:0017049 [GTP-Rho binding]
GO:0030036 [actin cytoskeleton organization]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031274 [positive regulation of pseudopodium assembly]
GO:0031334 [positive regulation of protein complex assembly]
GO:0043547 [positive regulation of GTPase activity]
Show all
 210 aa
22.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.