Tissue expression of KLHL1 - Summary - The Human Protein Atlas

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KLHL1

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	KLHL1
Gene description	Kelch-like family member 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (cerebral cortex)
GTEx:	Group enriched (hypothalamus, cerebellum)
FANTOM5:	Tissue enhanced (pituitary gland, cerebellum, caudate)

Protein evidence

Evidence at transcript level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. External characterization data indicates expression in substantia nigra and hypothalamus.
Reliability score	Uncertain based on 1 antibody. HPA021196
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (hypothalamus, cerebellum)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (pituitary gland, cerebellum, caudate)

GENE INFORMATION
Gene name	KLHL1 (HGNC Symbol)
Synonyms	FLJ30047, KIAA1490, MRP2
Description	Kelch-like family member 1 (HGNC Symbol)
Entrez gene summary	The KLHL1 protein belongs to a family of actin-organizing proteins related to Drosophila Kelch (Nemes et al., 2000 [PubMed 10888605]).[supplied by OMIM, Feb 2010]
Chromosome	13
Cytoband	q21.33
Chromosome location (bp)	69700594 - 70108493
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000150361 (version 83.38)
Entrez gene	57626
UniProt	Q9NR64 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9NR64
Antibodypedia	KLHL1 antibodies

PROTEIN BROWSER

KLHL1-001	KLHL1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KLHL1-001 ENSP00000367075 ENST00000377844	Q9NR64 [Direct mapping] Kelch-like protein 1 Show all	Predicted intracellular proteins Show all	GO:0003779 [actin binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0007626 [locomotory behavior] GO:0007628 [adult walking behavior] GO:0016358 [dendrite development] GO:0016567 [protein ubiquitination] GO:0021680 [cerebellar Purkinje cell layer development] GO:0030036 [actin cytoskeleton organization] GO:0030425 [dendrite] GO:0031463 [Cul3-RING ubiquitin ligase complex] GO:0043025 [neuronal cell body] Show all	748 aa 82.7 kDa	No	0
KLHL1-201 ENSP00000439602 ENST00000545028	F5H1J3 [Direct mapping] Kelch-like protein 1 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	687 aa 75.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.