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UBC

GENERAL INFORMATION

Gene name

 UBC

Gene description

 Ubiquitin C

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 12
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General nuclear and cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 4 antibodies.
HPA041344 , HPA049132 , CAB000362 , CAB005419
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 UBC

Synonyms

Description

 Ubiquitin C (HGNC Symbol)

Entrez gene summary

 This gene represents a ubiquitin gene, ubiquitin C. The encoded protein is a polyubiquitin precursor. Conjugation of ubiquitin monomers or polymers can lead to various effects within a cell, depending on the residues to which ubiquitin is conjugated. Ubiquitination has been associated with protein degradation, DNA repair, cell cycle regulation, kinase modification, endocytosis, and regulation of other cell signaling pathways. [provided by RefSeq, Aug 2010]

Chromosome

 12

Cytoband

 q24.31

Chromosome location (bp)

 124911604 - 124917368

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000150991 (version 83.38)

Entrez gene

 7316

UniProt

 P0CG48 (UniProt - Evidence at protein level)

neXtProt

 NX_P0CG48

Antibodypedia

 UBC antibodies

PROTEIN BROWSER
«
UBC-001
UBC-003
UBC-007
UBC-008
UBC-009
UBC-011
UBC-012
UBC-013
UBC-014
UBC-015
UBC-016
UBC-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UBC-001
ENSP00000344818
ENST00000339647
P0CG48 [Direct mapping]
Polyubiquitin-C Ubiquitin
Show all
Predicted intracellular proteins
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000187 [activation of MAPK activity]
GO:0000209 [protein polyubiquitination]
GO:0000278 [mitotic cell cycle]
GO:0000423 [macromitophagy]
GO:0000715 [nucleotide-excision repair, DNA damage recognition]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0002020 [protease binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0005978 [glycogen biosynthetic process]
GO:0006006 [glucose metabolic process]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006297 [nucleotide-excision repair, DNA gap filling]
GO:0006302 [double-strand break repair]
GO:0006351 [transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007219 [Notch signaling pathway]
GO:0007220 [Notch receptor processing]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007254 [JNK cascade]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0007623 [circadian rhythm]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010008 [endosome membrane]
GO:0010467 [gene expression]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0010939 [regulation of necrotic cell death]
GO:0012501 [programmed cell death]
GO:0016032 [viral process]
GO:0016197 [endosomal transport]
GO:0016236 [macroautophagy]
GO:0019058 [viral life cycle]
GO:0019068 [virion assembly]
GO:0019082 [viral protein processing]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019985 [translesion synthesis]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0030666 [endocytic vesicle membrane]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0032479 [regulation of type I interferon production]
GO:0032480 [negative regulation of type I interferon production]
GO:0032481 [positive regulation of type I interferon production]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0033683 [nucleotide-excision repair, DNA incision]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0034220 [ion transmembrane transport]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0036297 [interstrand cross-link repair]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042276 [error-prone translesion synthesis]
GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I]
GO:0042769 [DNA damage response, detection of DNA damage]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043488 [regulation of mRNA stability]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050852 [T cell receptor signaling pathway]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0055085 [transmembrane transport]
GO:0061024 [membrane organization]
GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0070062 [extracellular exosome]
GO:0070266 [necroptotic process]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0070911 [global genome nucleotide-excision repair]
GO:0070987 [error-free translesion synthesis]
GO:0071456 [cellular response to hypoxia]
GO:0075733 [intracellular transport of virus]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0097190 [apoptotic signaling pathway]
GO:0097300 [programmed necrotic cell death]
Show all
 685 aa
77 kDa 		No 0
UBC-003
ENSP00000443053
ENST00000538617
Q96C32 [Direct mapping]
Polyubiquitin-C; UBC protein
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
Show all
 305 aa
34.3 kDa 		No 0
UBC-007
ENSP00000441543
ENST00000536769
P0CG48 [Direct mapping]
Polyubiquitin-C Ubiquitin
Show all
Predicted intracellular proteins
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000187 [activation of MAPK activity]
GO:0000209 [protein polyubiquitination]
GO:0000278 [mitotic cell cycle]
GO:0000423 [macromitophagy]
GO:0000715 [nucleotide-excision repair, DNA damage recognition]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0002020 [protease binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0005978 [glycogen biosynthetic process]
GO:0006006 [glucose metabolic process]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006297 [nucleotide-excision repair, DNA gap filling]
GO:0006302 [double-strand break repair]
GO:0006351 [transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007219 [Notch signaling pathway]
GO:0007220 [Notch receptor processing]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007254 [JNK cascade]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0007623 [circadian rhythm]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010008 [endosome membrane]
GO:0010467 [gene expression]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0010939 [regulation of necrotic cell death]
GO:0010992 [ubiquitin homeostasis]
GO:0012501 [programmed cell death]
GO:0016032 [viral process]
GO:0016197 [endosomal transport]
GO:0016236 [macroautophagy]
GO:0019058 [viral life cycle]
GO:0019068 [virion assembly]
GO:0019082 [viral protein processing]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019985 [translesion synthesis]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0030666 [endocytic vesicle membrane]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0032479 [regulation of type I interferon production]
GO:0032480 [negative regulation of type I interferon production]
GO:0032481 [positive regulation of type I interferon production]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0033683 [nucleotide-excision repair, DNA incision]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0034220 [ion transmembrane transport]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0036297 [interstrand cross-link repair]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042276 [error-prone translesion synthesis]
GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I]
GO:0042769 [DNA damage response, detection of DNA damage]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043209 [myelin sheath]
GO:0043488 [regulation of mRNA stability]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050852 [T cell receptor signaling pathway]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0055085 [transmembrane transport]
GO:0061024 [membrane organization]
GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0070062 [extracellular exosome]
GO:0070266 [necroptotic process]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0070911 [global genome nucleotide-excision repair]
GO:0070987 [error-free translesion synthesis]
GO:0071456 [cellular response to hypoxia]
GO:0075733 [intracellular transport of virus]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0097190 [apoptotic signaling pathway]
GO:0097300 [programmed necrotic cell death]
Show all
 685 aa
77 kDa 		No 0
UBC-008
ENSP00000441556
ENST00000542416
F5GZ39 [Direct mapping]
Polyubiquitin-C
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
Show all
 61 aa
6.9 kDa 		No 0
UBC-009
ENSP00000442800
ENST00000540351
F5H747 [Direct mapping]
Polyubiquitin-C
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
Show all
 161 aa
18.2 kDa 		No 0
UBC-011
ENSP00000441238
ENST00000540700
F5GYU3 [Direct mapping]
Polyubiquitin-C
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
Show all
 134 aa
15 kDa 		No 0
UBC-012
ENSP00000438289
ENST00000546271
F5H2Z3 [Direct mapping]
Polyubiquitin-C
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
Show all
 136 aa
15.3 kDa 		No 0
UBC-013
ENSP00000437452
ENST00000535859
F5H6Q2 [Direct mapping]
Polyubiquitin-C
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
Show all
 123 aa
13.8 kDa 		No 0
UBC-014
ENSP00000445337
ENST00000541645
F5H388 [Direct mapping]
Polyubiquitin-C
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
Show all
 155 aa
17.5 kDa 		No 0
UBC-015
ENSP00000439492
ENST00000535131
F5H265 [Direct mapping]
Polyubiquitin-C
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
Show all
 149 aa
16.8 kDa 		No 0
UBC-016
ENSP00000440205
ENST00000541272
F5GXK7 [Direct mapping]
Polyubiquitin-C
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
Show all
 169 aa
19 kDa 		No 0
UBC-201
ENSP00000438394
ENST00000546120
Q5PY61 [Direct mapping]
Polyubiquitin-C; Ubiquitin C splice variant
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
Show all
 229 aa
25.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.