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Hepatocellular carcinomas exhibited moderate to strong cytoplasmic positivity. Several prostate cancers and malignant gliomas showed moderate staining. The rest of the tumors were negative.
Cancer tissues showed weak to moderate nuclear staining with additional cytoplasmic positivity in few cases. Few cases of carcinoid and urothelial cancers displayed strong positivity.
GENE INFORMATION
Gene name
SETBP1 (HGNC Symbol)
Synonyms
KIAA0437, SEB
Description
SET binding protein 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a protein which contains a several motifs including a ski homology region and a SET-binding region in addition to three nuclear localization signals. The encoded protein has been shown to bind the SET nuclear oncogene which is involved in DNA replication. Mutations in this gene are associated with Schinzel-Giedion midface retraction syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Germline Mutations Disease related genes Protein evidence (Kim et al 2014)
