Cell atlas - SETBP1 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

SETBP1

TISSUE

premium

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nuclear bodies
	Nucleus

Human cell
	Cytosol
	Nucleoplasm

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	SETBP1
Gene description	SET binding protein 1
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus. In addition localized to the cytosol & nuclear bodies.
RNA cell category	Cell line enhanced (Karpas-707, AF22)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (supported)
Additional location	In addition localized to the Nuclear bodies (supported), Cytosol (uncertain)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA049022
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (Karpas-707, AF22) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus. In addition localized to the cytosol & nuclear bodies.

Main location

Nucleus (supported)

Additional location

Nuclear bodies (supported), Cytosol (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA049022	HaCaT	Nucleus
			Nuclear bodies
			Cytosol
	HPA049022	U-2 OS	Nucleoplasm
	HPA049022	U-251 MG	No staining

GENE INFORMATION
Gene name	SETBP1 (HGNC Symbol)
Synonyms	KIAA0437, SEB
Description	SET binding protein 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein which contains a several motifs including a ski homology region and a SET-binding region in addition to three nuclear localization signals. The encoded protein has been shown to bind the SET nuclear oncogene which is involved in DNA replication. Mutations in this gene are associated with Schinzel-Giedion midface retraction syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Chromosome	18
Cytoband	q12.3
Chromosome location (bp)	44680173 - 45068510
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000152217 (version 83.38)
Entrez gene	26040
UniProt	Q9Y6X0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y6X0
Antibodypedia	SETBP1 antibodies

PROTEIN BROWSER

SETBP1-001	SETBP1-002	SETBP1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SETBP1-001 ENSP00000282030 ENST00000282030	Q9Y6X0 [Direct mapping] SET-binding protein Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Germline Mutations Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] Show all	1596 aa 175 kDa	No	0
SETBP1-002 ENSP00000390687 ENST00000426838	Q9Y6X0 [Direct mapping] SET-binding protein Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Germline Mutations Disease related genes Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] Show all	242 aa 26.4 kDa	No	0
SETBP1-003 ENSP00000468506 ENST00000591940	K7ES17 [Direct mapping] SET-binding protein Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Germline Mutations Show all		137 aa 14.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.