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RPIA

GENERAL INFORMATION

Gene name

 RPIA

Gene description

 Ribose 5-phosphate isomerase A

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA042620
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 RPIA

Synonyms

Description

 Ribose 5-phosphate isomerase A (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is an enzyme, which catalyzes the reversible conversion between ribose-5-phosphate and ribulose-5-phosphate in the pentose-phosphate pathway. This gene is highly conserved in most organisms. The enzyme plays an essential role in the carbohydrate metabolism. Mutations in this gene cause ribose 5-phosphate isomerase deficiency. A pseudogene is found on chromosome 18. [provided by RefSeq, Mar 2010]

Chromosome

 2

Cytoband

 p11.2

Chromosome location (bp)

 88691644 - 88750935

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000153574 (version 83.38)

Entrez gene

 22934

UniProt

 P49247 (UniProt - Evidence at protein level)

neXtProt

 NX_P49247

Antibodypedia

 RPIA antibodies

PROTEIN BROWSER
RPIA-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RPIA-001
ENSP00000283646
ENST00000283646
P49247 [Direct mapping]
Ribose-5-phosphate isomerase
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Enzymes
   ENZYME proteins
   Isomerase
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004751 [ribose-5-phosphate isomerase activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006098 [pentose-phosphate shunt]
GO:0009052 [pentose-phosphate shunt, non-oxidative branch]
GO:0019693 [ribose phosphate metabolic process]
GO:0030246 [carbohydrate binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044281 [small molecule metabolic process]
GO:0048029 [monosaccharide binding]
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 311 aa
33.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.