Expression of SLC16A1 in cancer - Summary

CANCER ATLAS

Gene description

Solute carrier family 16 (monocarboxylate transporter), member 1

Protein class

Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA003324

GENE INFORMATION
Gene name	SLC16A1 (HGNC Symbol)
Synonyms	MCT, MCT1
Description	Solute carrier family 16 (monocarboxylate transporter), member 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2009]
Chromosome	1
Cytoband	p13.2
Chromosome location (bp)	112911847 - 112957013
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000155380 (version 83.38)
Entrez gene	6566
UniProt	P53985 (UniProt - Evidence at protein level)
neXtProt	NX_P53985
Antibodypedia	SLC16A1 antibodies

PROTEIN BROWSER

SLC16A1-001	SLC16A1-002	SLC16A1-003	SLC16A1-005	SLC16A1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC16A1-001 ENSP00000358640 ENST00000369626	P53985 [Direct mapping] Monocarboxylate transporter 1 A0A024R0H1 [Target identity:100%; Query identity:100%] Solute carrier family 16 (Monocarboxylic acid transporters), member 1, isoform CRA_b Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005813 [centrosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006090 [pyruvate metabolic process] GO:0007596 [blood coagulation] GO:0008028 [monocarboxylic acid transmembrane transporter activity] GO:0015129 [lactate transmembrane transporter activity] GO:0015130 [mevalonate transmembrane transporter activity] GO:0015293 [symporter activity] GO:0015718 [monocarboxylic acid transport] GO:0015728 [mevalonate transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0035879 [plasma membrane lactate transport] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0050900 [leukocyte migration] GO:0051297 [centrosome organization] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] Show all	500 aa 53.9 kDa	No	>9
SLC16A1-002 ENSP00000416167 ENST00000458229	Q5T8R5 [Direct mapping] Monocarboxylate transporter 1; Solute carrier family 16 (Monocarboxylic acid transporters), member 1, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0008028 [monocarboxylic acid transmembrane transporter activity] GO:0015129 [lactate transmembrane transporter activity] GO:0015718 [monocarboxylic acid transport] GO:0016021 [integral component of membrane] GO:0035879 [plasma membrane lactate transport] GO:0055085 [transmembrane transport] Show all	456 aa 49.2 kDa	No	>9
SLC16A1-003 ENSP00000397106 ENST00000429288	Q5T8R4 [Direct mapping] Monocarboxylate transporter 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005887 [integral component of plasma membrane] GO:0015129 [lactate transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0035879 [plasma membrane lactate transport] GO:0055085 [transmembrane transport] Show all	215 aa 22.5 kDa	No	6
SLC16A1-005 ENSP00000399104 ENST00000443580	Q5T8R3 [Direct mapping] Monocarboxylate transporter 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0015129 [lactate transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0035879 [plasma membrane lactate transport] GO:0055085 [transmembrane transport] Show all	296 aa 31.7 kDa	No	7
SLC16A1-201 ENSP00000441065 ENST00000538576	P53985 [Direct mapping] Monocarboxylate transporter 1 A0A024R0H1 [Target identity:100%; Query identity:100%] Solute carrier family 16 (Monocarboxylic acid transporters), member 1, isoform CRA_b Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005813 [centrosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006090 [pyruvate metabolic process] GO:0006629 [lipid metabolic process] GO:0007596 [blood coagulation] GO:0008028 [monocarboxylic acid transmembrane transporter activity] GO:0015129 [lactate transmembrane transporter activity] GO:0015130 [mevalonate transmembrane transporter activity] GO:0015293 [symporter activity] GO:0015718 [monocarboxylic acid transport] GO:0015728 [mevalonate transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0032094 [response to food] GO:0035873 [lactate transmembrane transport] GO:0035879 [plasma membrane lactate transport] GO:0042593 [glucose homeostasis] GO:0042803 [protein homodimerization activity] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0050796 [regulation of insulin secretion] GO:0050900 [leukocyte migration] GO:0051297 [centrosome organization] GO:0051780 [behavioral response to nutrient] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0071407 [cellular response to organic cyclic compound] GO:0097159 [organic cyclic compound binding] Show all	500 aa 53.9 kDa	No	>9