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SLC16A1

GENERAL INFORMATION

Gene name

 SLC16A1

Gene description

 Solute carrier family 16 (monocarboxylate transporter), member 1

Protein class

 Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA003324
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SLC16A1 (HGNC Symbol)

Synonyms

 MCT, MCT1

Description

 Solute carrier family 16 (monocarboxylate transporter), member 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2009]

Chromosome

 1

Cytoband

 p13.2

Chromosome location (bp)

 112911847 - 112957013

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000155380 (version 83.38)

Entrez gene

 6566

UniProt

 P53985 (UniProt - Evidence at protein level)

neXtProt

 NX_P53985

Antibodypedia

 SLC16A1 antibodies

PROTEIN BROWSER
SLC16A1-001
SLC16A1-002
SLC16A1-003
SLC16A1-005
SLC16A1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC16A1-001
ENSP00000358640
ENST00000369626
P53985 [Direct mapping]
Monocarboxylate transporter 1
A0A024R0H1 [Target identity:100%; Query identity:100%]
Solute carrier family 16 (Monocarboxylic acid transporters), member 1, isoform CRA_b
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005813 [centrosome]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006090 [pyruvate metabolic process]
GO:0007596 [blood coagulation]
GO:0008028 [monocarboxylic acid transmembrane transporter activity]
GO:0015129 [lactate transmembrane transporter activity]
GO:0015130 [mevalonate transmembrane transporter activity]
GO:0015293 [symporter activity]
GO:0015718 [monocarboxylic acid transport]
GO:0015728 [mevalonate transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0035879 [plasma membrane lactate transport]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0050900 [leukocyte migration]
GO:0051297 [centrosome organization]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
Show all
 500 aa
53.9 kDa 		No >9
SLC16A1-002
ENSP00000416167
ENST00000458229
Q5T8R5 [Direct mapping]
Monocarboxylate transporter 1; Solute carrier family 16 (Monocarboxylic acid transporters), member 1, isoform CRA_a
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0008028 [monocarboxylic acid transmembrane transporter activity]
GO:0015129 [lactate transmembrane transporter activity]
GO:0015718 [monocarboxylic acid transport]
GO:0016021 [integral component of membrane]
GO:0035879 [plasma membrane lactate transport]
GO:0055085 [transmembrane transport]
Show all
 456 aa
49.2 kDa 		No >9
SLC16A1-003
ENSP00000397106
ENST00000429288
Q5T8R4 [Direct mapping]
Monocarboxylate transporter 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005887 [integral component of plasma membrane]
GO:0015129 [lactate transmembrane transporter activity]
GO:0016021 [integral component of membrane]
GO:0035879 [plasma membrane lactate transport]
GO:0055085 [transmembrane transport]
Show all
 215 aa
22.5 kDa 		No 6
SLC16A1-005
ENSP00000399104
ENST00000443580
Q5T8R3 [Direct mapping]
Monocarboxylate transporter 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0015129 [lactate transmembrane transporter activity]
GO:0016021 [integral component of membrane]
GO:0035879 [plasma membrane lactate transport]
GO:0055085 [transmembrane transport]
Show all
 296 aa
31.7 kDa 		No 7
SLC16A1-201
ENSP00000441065
ENST00000538576
P53985 [Direct mapping]
Monocarboxylate transporter 1
A0A024R0H1 [Target identity:100%; Query identity:100%]
Solute carrier family 16 (Monocarboxylic acid transporters), member 1, isoform CRA_b
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005813 [centrosome]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006090 [pyruvate metabolic process]
GO:0006629 [lipid metabolic process]
GO:0007596 [blood coagulation]
GO:0008028 [monocarboxylic acid transmembrane transporter activity]
GO:0015129 [lactate transmembrane transporter activity]
GO:0015130 [mevalonate transmembrane transporter activity]
GO:0015293 [symporter activity]
GO:0015718 [monocarboxylic acid transport]
GO:0015728 [mevalonate transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0032094 [response to food]
GO:0035873 [lactate transmembrane transport]
GO:0035879 [plasma membrane lactate transport]
GO:0042593 [glucose homeostasis]
GO:0042803 [protein homodimerization activity]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0050796 [regulation of insulin secretion]
GO:0050900 [leukocyte migration]
GO:0051297 [centrosome organization]
GO:0051780 [behavioral response to nutrient]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0071407 [cellular response to organic cyclic compound]
GO:0097159 [organic cyclic compound binding]
Show all
 500 aa
53.9 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.