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Group enriched (caudate, brain, hippocampus, cerebellum, pituitary gland, retina)
Protein evidence
Evidence at protein level
Protein expression
Cytoplasmic expression in several cell types.
DATA RELIABILITY
Data reliability description
Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded.
Protein phosphatase 2, regulatory subunit B, beta (HGNC Symbol)
Entrez gene summary
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in this gene cause autosomal dominant spinocerebellar ataxia 12 (SCA12), a disease caused by degeneration of the cerebellum, sometimes involving the brainstem and spinal cord, and in resulting in poor coordination of speech and body movements. Multiple alternatively spliced variants, which encode different isoforms, have been identified for this gene. The 5' UTR of some of these variants includes a CAG trinucleotide repeat sequence (7-28 copies) that can be expanded to 66-78 copies in cases of SCA12. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
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GO:0000159 [protein phosphatase type 2A complex] GO:0005515 [protein binding] GO:0008601 [protein phosphatase type 2A regulator activity] GO:0034047 [regulation of protein phosphatase type 2A activity]
Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000159 [protein phosphatase type 2A complex] GO:0008601 [protein phosphatase type 2A regulator activity] GO:0034047 [regulation of protein phosphatase type 2A activity]
