Cell atlas - TYSND1 - The Human Protein Atlas

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TYSND1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Centrosome
	Cytosol
	Nucleoplasm

Human cell
	Centrosome
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	TYSND1
Gene description	Trypsin domain containing 1
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the centrosome & nucleoplasm. In addition localized to the cytosol.
RNA cell category	Cell line enhanced (PC-3)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (uncertain), Centrosome (uncertain)
Additional location	In addition localized to the Cytosol (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA030304
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (PC-3) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the centrosome & nucleoplasm. In addition localized to the cytosol.

Main location

Nucleoplasm (uncertain), Centrosome (uncertain)

Additional location

Cytosol (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA030304	A-431	Nucleoplasm
	HPA030304	A-431	Centrosome
	HPA030304	U-2 OS	Nucleoplasm
			Centrosome
			Cytosol
	HPA030304	U-251 MG	Nucleoplasm
	HPA030304	U-251 MG	Centrosome

GENE INFORMATION
Gene name	TYSND1 (HGNC Symbol)
Synonyms	MGC34695, NET41
Description	Trypsin domain containing 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a protease that removes the N-terminal peroxisomal targeting signal (PTS2) from proteins produced in the cytosol, thereby facilitating their import into the peroxisome. The encoded protein is also capable of removing the C-terminal peroxisomal targeting signal (PTS1) from proteins in the peroxisomal matrix. The full-length protein undergoes self-cleavage to produce shorter, potentially inactive, peptides. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]
Chromosome	10
Cytoband	q22.1
Chromosome location (bp)	70137981 - 70146676
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000156521 (version 83.38)
Entrez gene	219743
UniProt	Q2T9J0 (UniProt - Evidence at protein level)
neXtProt	NX_Q2T9J0
Antibodypedia	TYSND1 antibodies

PROTEIN BROWSER

TYSND1-001	TYSND1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TYSND1-001 ENSP00000287078 ENST00000287078	Q2T9J0 [Direct mapping] Peroxisomal leader peptide-processing protease Peroxisomal leader peptide-processing protease, 15 kDa form Peroxisomal leader peptide-processing protease, 45 kDa form Show all	Enzymes Peptidases Serine-type peptidases SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002020 [protease binding] GO:0004252 [serine-type endopeptidase activity] GO:0005777 [peroxisome] GO:0006508 [proteolysis] GO:0016020 [membrane] GO:0016485 [protein processing] GO:0031998 [regulation of fatty acid beta-oxidation] GO:0042802 [identical protein binding] GO:0051260 [protein homooligomerization] Show all	566 aa 59.3 kDa	No	0
TYSND1-002 ENSP00000335673 ENST00000335494	Q2T9J0 [Direct mapping] Peroxisomal leader peptide-processing protease Peroxisomal leader peptide-processing protease, 15 kDa form Peroxisomal leader peptide-processing protease, 45 kDa form Show all	Enzymes Peptidases Serine-type peptidases SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002020 [protease binding] GO:0004252 [serine-type endopeptidase activity] GO:0005777 [peroxisome] GO:0006508 [proteolysis] GO:0016020 [membrane] GO:0016485 [protein processing] GO:0031998 [regulation of fatty acid beta-oxidation] GO:0042802 [identical protein binding] GO:0051260 [protein homooligomerization] Show all	398 aa 41.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.