Tissue expression of TYSND1 - Summary - The Human Protein Atlas

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TYSND1

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	TYSND1
Gene description	Trypsin domain containing 1
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA030304
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	TYSND1 (HGNC Symbol)
Synonyms	MGC34695, NET41
Description	Trypsin domain containing 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a protease that removes the N-terminal peroxisomal targeting signal (PTS2) from proteins produced in the cytosol, thereby facilitating their import into the peroxisome. The encoded protein is also capable of removing the C-terminal peroxisomal targeting signal (PTS1) from proteins in the peroxisomal matrix. The full-length protein undergoes self-cleavage to produce shorter, potentially inactive, peptides. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]
Chromosome	10
Cytoband	q22.1
Chromosome location (bp)	70137981 - 70146676
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000156521 (version 83.38)
Entrez gene	219743
UniProt	Q2T9J0 (UniProt - Evidence at protein level)
neXtProt	NX_Q2T9J0
Antibodypedia	TYSND1 antibodies

PROTEIN BROWSER

TYSND1-001	TYSND1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TYSND1-001 ENSP00000287078 ENST00000287078	Q2T9J0 [Direct mapping] Peroxisomal leader peptide-processing protease Peroxisomal leader peptide-processing protease, 15 kDa form Peroxisomal leader peptide-processing protease, 45 kDa form Show all	Enzymes Peptidases Serine-type peptidases SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002020 [protease binding] GO:0004252 [serine-type endopeptidase activity] GO:0005777 [peroxisome] GO:0006508 [proteolysis] GO:0016020 [membrane] GO:0016485 [protein processing] GO:0031998 [regulation of fatty acid beta-oxidation] GO:0042802 [identical protein binding] GO:0051260 [protein homooligomerization] Show all	566 aa 59.3 kDa	No	0
TYSND1-002 ENSP00000335673 ENST00000335494	Q2T9J0 [Direct mapping] Peroxisomal leader peptide-processing protease Peroxisomal leader peptide-processing protease, 15 kDa form Peroxisomal leader peptide-processing protease, 45 kDa form Show all	Enzymes Peptidases Serine-type peptidases SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002020 [protease binding] GO:0004252 [serine-type endopeptidase activity] GO:0005777 [peroxisome] GO:0006508 [proteolysis] GO:0016020 [membrane] GO:0016485 [protein processing] GO:0031998 [regulation of fatty acid beta-oxidation] GO:0042802 [identical protein binding] GO:0051260 [protein homooligomerization] Show all	398 aa 41.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.