Expression of AGRP in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Agouti related neuropeptide

Protein class

Disease related genes, Plasma proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA041017

GENE INFORMATION
Gene name	AGRP (HGNC Symbol)
Synonyms	Agrt, ART, ASIP2
Description	Agouti related neuropeptide (HGNC Symbol)
Entrez gene summary	This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity. [provided by RefSeq, Dec 2009]
Chromosome	16
Cytoband	q22.1
Chromosome location (bp)	67482571 - 67483813
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000159723 (version 83.38)
Entrez gene	181
UniProt	O00253 (UniProt - Evidence at protein level)
neXtProt	NX_O00253
Antibodypedia	AGRP antibodies

PROTEIN BROWSER

AGRP-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AGRP-001 ENSP00000290953 ENST00000290953	O00253 [Direct mapping] Agouti-related protein C6SUN5 [Target identity:100%; Query identity:100%] Agouti related protein homolog (Mouse); Agouti-related protein Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Show all	GO:0005102 [receptor binding] GO:0005184 [neuropeptide hormone activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005796 [Golgi lumen] GO:0007218 [neuropeptide signaling pathway] GO:0007623 [circadian rhythm] GO:0007631 [feeding behavior] GO:0008343 [adult feeding behavior] GO:0009648 [photoperiodism] GO:0009755 [hormone-mediated signaling pathway] GO:0032868 [response to insulin] GO:0042755 [eating behavior] GO:0043025 [neuronal cell body] GO:0060135 [maternal process involved in female pregnancy] GO:0060259 [regulation of feeding behavior] GO:0070062 [extracellular exosome] GO:2000253 [positive regulation of feeding behavior] Show all	132 aa 14.4 kDa	Yes	0