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AGRP

GENERAL INFORMATION

Gene name

 AGRP

Gene description

 Agouti related neuropeptide

Protein class

 Disease related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (epididymis, adrenal gland)
GTEx:Group enriched (hypothalamus, adrenal gland, lung)
FANTOM5:Tissue enriched (epididymis)

Protein evidence

 Evidence at protein level

Protein expression

 Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA041017
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Adrenal gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (epididymis, adrenal gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (hypothalamus, adrenal gland, lung)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (epididymis)

GENE INFORMATION

Gene name

 AGRP (HGNC Symbol)

Synonyms

 Agrt, ART, ASIP2

Description

 Agouti related neuropeptide (HGNC Symbol)

Entrez gene summary

 This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity. [provided by RefSeq, Dec 2009]

Chromosome

 16

Cytoband

 q22.1

Chromosome location (bp)

 67482571 - 67483813

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000159723 (version 83.38)

Entrez gene

 181

UniProt

 O00253 (UniProt - Evidence at protein level)

neXtProt

 NX_O00253

Antibodypedia

 AGRP antibodies

PROTEIN BROWSER
AGRP-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AGRP-001
ENSP00000290953
ENST00000290953
O00253 [Direct mapping]
Agouti-related protein
C6SUN5 [Target identity:100%; Query identity:100%]
Agouti related protein homolog (Mouse); Agouti-related protein
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Show all
GO:0005102 [receptor binding]
GO:0005184 [neuropeptide hormone activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005796 [Golgi lumen]
GO:0007218 [neuropeptide signaling pathway]
GO:0007623 [circadian rhythm]
GO:0007631 [feeding behavior]
GO:0008343 [adult feeding behavior]
GO:0009648 [photoperiodism]
GO:0009755 [hormone-mediated signaling pathway]
GO:0032868 [response to insulin]
GO:0042755 [eating behavior]
GO:0043025 [neuronal cell body]
GO:0060135 [maternal process involved in female pregnancy]
GO:0060259 [regulation of feeding behavior]
GO:0070062 [extracellular exosome]
GO:2000253 [positive regulation of feeding behavior]
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 132 aa
14.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.