Cell atlas - AGRP - The Human Protein Atlas

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AGRP

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	AGRP
Gene description	Agouti related neuropeptide
Protein class	Disease related genes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Not detected
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Not detected Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	AGRP (HGNC Symbol)
Synonyms	Agrt, ART, ASIP2
Description	Agouti related neuropeptide (HGNC Symbol)
Entrez gene summary	This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity. [provided by RefSeq, Dec 2009]
Chromosome	16
Cytoband	q22.1
Chromosome location (bp)	67482571 - 67483813
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000159723 (version 83.38)
Entrez gene	181
UniProt	O00253 (UniProt - Evidence at protein level)
neXtProt	NX_O00253
Antibodypedia	AGRP antibodies

PROTEIN BROWSER

AGRP-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AGRP-001 ENSP00000290953 ENST00000290953	O00253 [Direct mapping] Agouti-related protein C6SUN5 [Target identity:100%; Query identity:100%] Agouti related protein homolog (Mouse); Agouti-related protein Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Show all	GO:0005102 [receptor binding] GO:0005184 [neuropeptide hormone activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005796 [Golgi lumen] GO:0007218 [neuropeptide signaling pathway] GO:0007623 [circadian rhythm] GO:0007631 [feeding behavior] GO:0008343 [adult feeding behavior] GO:0009648 [photoperiodism] GO:0009755 [hormone-mediated signaling pathway] GO:0032868 [response to insulin] GO:0042755 [eating behavior] GO:0043025 [neuronal cell body] GO:0060135 [maternal process involved in female pregnancy] GO:0060259 [regulation of feeding behavior] GO:0070062 [extracellular exosome] GO:2000253 [positive regulation of feeding behavior] Show all	132 aa 14.4 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.