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ZYX

GENERAL INFORMATION

Gene name

 ZYX

Gene description

 Zyxin

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Expression in subsets of immune cells as well as smooth muscle, lung macrophages, myoepithelial cells, bone marrow and platelets.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 4 antibodies.
HPA004835 , HPA073497 , CAB009321 , CAB075747
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ZYX

Synonyms

Description

 Zyxin (HGNC Symbol)

Entrez gene summary

 Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 q34

Chromosome location (bp)

 143381080 - 143391111

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000159840 (version 83.38)

Entrez gene

 7791

UniProt

 Q15942 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15942

Antibodypedia

 ZYX antibodies

PROTEIN BROWSER
ZYX-001
ZYX-003
ZYX-005
ZYX-006
ZYX-007
ZYX-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ZYX-001
ENSP00000324422
ENST00000322764
Q15942 [Direct mapping]
Zyxin
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005913 [cell-cell adherens junction]
GO:0005925 [focal adhesion]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007165 [signal transduction]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0008270 [zinc ion binding]
GO:0016032 [viral process]
GO:0043149 [stress fiber assembly]
GO:0044822 [poly(A) RNA binding]
GO:0050727 [regulation of inflammatory response]
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 572 aa
61.3 kDa 		No 0
ZYX-003
ENSP00000403714
ENST00000446634
C9JJK5 [Direct mapping]
Zyxin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008270 [zinc ion binding]
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 171 aa
19.1 kDa 		No 0
ZYX-005
ENSP00000413467
ENST00000449630
H7C3R3 [Direct mapping]
Zyxin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 178 aa
18.6 kDa 		No 0
ZYX-006
ENSP00000346417
ENST00000354434
H0Y2Y8 [Direct mapping]
Zyxin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005925 [focal adhesion]
GO:0008270 [zinc ion binding]
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 540 aa
57.6 kDa 		No 0
ZYX-007
ENSP00000376642
ENST00000392910
Q15942 [Direct mapping]
Zyxin
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005913 [cell-cell adherens junction]
GO:0005925 [focal adhesion]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007165 [signal transduction]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0008270 [zinc ion binding]
GO:0016032 [viral process]
GO:0043149 [stress fiber assembly]
GO:0044822 [poly(A) RNA binding]
Show all
 415 aa
45.1 kDa 		No 0
ZYX-010
ENSP00000400537
ENST00000457235
C9IZ41 [Direct mapping]
Zyxin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 164 aa
17.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.