We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Moderate to strong nuclear staining was observed in colorectal, breast, prostate and several cases of endometrial, urothelial and liver cancers. Most gliomas, lymphomas, melanomas, lung, renal and testicular cancers were negative. Most cholangiocarcinomas showed distinct positivity while hepatocellular cancers were negative.
Most cancer tissues were negative or weakly stained. Breast, prostate, urothelial, cervical and colorectal cancers showed moderate to strong positivity.
GENE INFORMATION
Gene name
ZBTB7B (HGNC Symbol)
Synonyms
c-Krox, hcKrox, ZBTB15, ZFP67, ZNF857B
Description
Zinc finger and BTB domain containing 7B (HGNC Symbol)
Entrez gene summary
This gene encodes a zinc finger-containing transcription factor that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. It also functions as a transcriptional repressor of type I collagen genes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
O15156 [Direct mapping] Zinc finger and BTB domain-containing protein 7B
Show all
Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007275 [multicellular organismal development] GO:0007398 [ectoderm development] GO:0010628 [positive regulation of gene expression] GO:0030154 [cell differentiation] GO:0042803 [protein homodimerization activity] GO:0043370 [regulation of CD4-positive, alpha-beta T cell differentiation] GO:0043376 [regulation of CD8-positive, alpha-beta T cell differentiation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding]
O15156 [Direct mapping] Zinc finger and BTB domain-containing protein 7B
Show all
Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007275 [multicellular organismal development] GO:0007398 [ectoderm development] GO:0010628 [positive regulation of gene expression] GO:0030154 [cell differentiation] GO:0046872 [metal ion binding]
