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ZBTB7B

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GENERAL INFORMATION

Gene name

 ZBTB7B

Gene description

 Zinc finger and BTB domain containing 7B

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm.

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (validated)

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
HPA006811 , HPA025820
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm.

Main location

 Nucleoplasm (validated)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA025820 A-431 Nucleoplasm
HPA025820 U-2 OS Nucleus
HPA025820 U-251 MG Nucleoplasm
HPA006811 A-431 Nucleoplasm
HPA006811 U-2 OS Nucleoplasm
HPA006811 U-251 MG Nucleoplasm

GENE INFORMATION

Gene name

 ZBTB7B (HGNC Symbol)

Synonyms

 c-Krox, hcKrox, ZBTB15, ZFP67, ZNF857B

Description

 Zinc finger and BTB domain containing 7B (HGNC Symbol)

Entrez gene summary

 This gene encodes a zinc finger-containing transcription factor that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. It also functions as a transcriptional repressor of type I collagen genes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

Chromosome

 1

Cytoband

 q21.3

Chromosome location (bp)

 155002630 - 155018522

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000160685 (version 83.38)

Entrez gene

 51043

UniProt

 O15156 (UniProt - Evidence at protein level)

neXtProt

 NX_O15156

Antibodypedia

 ZBTB7B antibodies

PROTEIN BROWSER
ZBTB7B-001
ZBTB7B-002
ZBTB7B-201
ZBTB7B-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ZBTB7B-001
ENSP00000357411
ENST00000368426
O15156 [Direct mapping]
Zinc finger and BTB domain-containing protein 7B
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007275 [multicellular organismal development]
GO:0007398 [ectoderm development]
GO:0010628 [positive regulation of gene expression]
GO:0030154 [cell differentiation]
GO:0046872 [metal ion binding]
Show all
 539 aa
58 kDa 		No 0
ZBTB7B-002
ENSP00000292176
ENST00000292176
O15156 [Direct mapping]
Zinc finger and BTB domain-containing protein 7B
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007275 [multicellular organismal development]
GO:0007398 [ectoderm development]
GO:0010628 [positive regulation of gene expression]
GO:0030154 [cell differentiation]
GO:0046872 [metal ion binding]
Show all
 539 aa
58 kDa 		No 0
ZBTB7B-201
ENSP00000406286
ENST00000417934
O15156 [Direct mapping]
Zinc finger and BTB domain-containing protein 7B
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007275 [multicellular organismal development]
GO:0007398 [ectoderm development]
GO:0010628 [positive regulation of gene expression]
GO:0030154 [cell differentiation]
GO:0042803 [protein homodimerization activity]
GO:0043370 [regulation of CD4-positive, alpha-beta T cell differentiation]
GO:0043376 [regulation of CD8-positive, alpha-beta T cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
Show all
 573 aa
61.6 kDa 		No 0
ZBTB7B-202
ENSP00000438647
ENST00000535420
O15156 [Direct mapping]
Zinc finger and BTB domain-containing protein 7B
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007275 [multicellular organismal development]
GO:0007398 [ectoderm development]
GO:0010628 [positive regulation of gene expression]
GO:0030154 [cell differentiation]
GO:0046872 [metal ion binding]
Show all
 539 aa
58 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.